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10.1128/MCB.00206-17 http://scihub22266oqcxt.onion/10.1128/MCB.00206-17 C5615180!5615180 !28716950     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28716950 &cmd=llinks): Failed to open stream: HTTP request failed! 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Analysis of Small Critical Regions of Swi1 Conferring Prion Formation, Maintenance, and Transmission |pdf=|usr=}}{{28716950 }} gab.com Text Analysis of Small Critical Regions of Swi1 Conferring Prion Formation, Maintenance, and Transmission JO: Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28716950 #FOAvip Saccharomyces cerevisiae contains several prion elements, which are epigenetically transmitted as self-perpetuating protein conformations. One such prion is [SWI(+) ], whose protein determinant is Swi1, a subunit of the SWI/SNF chromatin-remodeling complex. We previously reported that [SWI(+) ] formation results in a partial loss-of-function phenotype of poor growth in nonglucose medium and abolishment of multicellular features. We also showed that the first 38 amino acids of Swi1 propagated [SWI(+)]. We show here that a region as small as the first 32 amino acids of Swi1 (Swi1(1-32)) can decorate [SWI(+)] aggregation and stably maintain and transmit [SWI(+)] independently of full-length Swi1. Regions smaller than Swi1(1-32) are either incapable of aggregation or unstably propagate [SWI(+)]. When fused to Sup35MC, the [PSI(+) ] determinant lacking its PrD, Swi1(1-31) and Swi1(1-32) can act as transferable prion domains (PrDs). The resulting fusions give rise to a novel chimeric prion, [SPS(+)], exhibiting [PSI(+)]-like nonsense suppression. Thus, an NH(2)-terminal region of ?30 amino acids of Swi1 contains all the necessary information for in vivo prion formation, maintenance, and transmission. This PrD is unique in size and composition: glutamine free, asparagine rich, and the smallest defined to date. Our findings broaden our understanding of what features allow a protein region to serve as a PrD. Twit Text FOAVip Analysis of Small Critical Regions of Swi1 Conferring Prion Formation, Maintenance, and Transmission ????Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28716950 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28716950 #FOAvip English Wikipedia <ref>{{Cite pmid|28716950 }}</ref> Analysis of Small Critical Regions of Swi1 Conferring Prion Formation, Maintenance, and Transmission #MMPMID28716950 Valtierra S ; Du Z ; Li L Mol Cell Biol 2017[Oct]; 37 (20 ): ä PMID28716950 show ga Saccharomyces cerevisiae contains several prion elements, which are epigenetically transmitted as self-perpetuating protein conformations. One such prion is [SWI(+) ], whose protein determinant is Swi1, a subunit of the SWI/SNF chromatin-remodeling complex. We previously reported that [SWI(+) ] formation results in a partial loss-of-function phenotype of poor growth in nonglucose medium and abolishment of multicellular features. We also showed that the first 38 amino acids of Swi1 propagated [SWI(+)]. We show here that a region as small as the first 32 amino acids of Swi1 (Swi1(1-32)) can decorate [SWI(+)] aggregation and stably maintain and transmit [SWI(+)] independently of full-length Swi1. Regions smaller than Swi1(1-32) are either incapable of aggregation or unstably propagate [SWI(+)]. When fused to Sup35MC, the [PSI(+) ] determinant lacking its PrD, Swi1(1-31) and Swi1(1-32) can act as transferable prion domains (PrDs). The resulting fusions give rise to a novel chimeric prion, [SPS(+)], exhibiting [PSI(+)]-like nonsense suppression. Thus, an NH(2)-terminal region of ?30 amino acids of Swi1 contains all the necessary information for in vivo prion formation, maintenance, and transmission. This PrD is unique in size and composition: glutamine free, asparagine rich, and the smallest defined to date. Our findings broaden our understanding of what features allow a protein region to serve as a PrD. |*Gene Expression Regulation, Fungal [MESH] |Acyltransferases/genetics/*metabolism [MESH] |Chromatin Assembly and Disassembly/*physiology [MESH] |Chromosomal Proteins, Non-Histone/metabolism [MESH] |Prion Proteins/*metabolism [MESH] |Prions/chemistry/*metabolism [MESH] |Saccharomyces cerevisiae Proteins/genetics/*metabolism [MESH] |Saccharomyces cerevisiae/*metabolism [MESH]Analysis of Small Critical Regions of Swi1 Conferring Prion Formation,(epmc).pdf DeepDyve Pubget Overpricing