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10.1016/j.celrep.2017.08.085 http://scihub22266oqcxt.onion/10.1016/j.celrep.2017.08.085 C5614515!5614515!28930687     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2017 ; 20 (12): 2944-54 Nephropedia Template TP {{tp|p=28930687|t=2017. The RAB2B-GARIL5 complex promotes cytosolic DNA-induced innate immune responses |pdf=|usr=}}{{28930687}} gab.com Text The RAB2B-GARIL5 complex promotes cytosolic DNA-induced innate immune responses JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28930687 #FOAvip Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces the IFN antiviral response. However, the regulatory mechanisms that mediate cGAS-triggered signaling have not been fully explored. Here, we show the involvement of a small GTPase RAB2B and its effector protein Golgi-associated RAB2B interactor-like 5 (GARIL5) in the cGAS-mediated IFN response. RAB2B-deficiency affects the IFN response induced by cytosolic DNA. Consistent with this, RAB2B-deficiency enhances replication of vaccinia virus, a DNA virus. After DNA stimulation, RAB2B colocalizes with stimulator of interferon genes (STING), the downstream signal mediator of cGAS, on the Golgi apparatus. GTP-binding activity of RAB2B is required for its localization on the Golgi apparatus and for recruitment of GARIL5. GARIL5 deficiency also affects the IFN response induced by cytosolic DNA and enhances replication of vaccinia virus. These findings indicate that the RAB2B-GARIL5 complex promotes IFN responses against DNA viruses by regulating the cGAS-STING signaling axis. Twit Text FOAVip The RAB2B-GARIL5 complex promotes cytosolic DNA-induced innate immune responses ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28930687 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28930687 #FOAvip English Wikipedia <ref>{{Cite pmid|28930687}}</ref> The RAB2B-GARIL5 complex promotes cytosolic DNA-induced innate immune responses #MMPMID28930687 Takahama M; Fukuda M; Ohbayashi N; Kozaki T; Misawa T; Okamoto T; Matsuura Y; Akira S; Saitoh T Cell Rep 2017[Sep]; 20 (12): 2944-54 PMID28930687show ga Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces the IFN antiviral response. However, the regulatory mechanisms that mediate cGAS-triggered signaling have not been fully explored. Here, we show the involvement of a small GTPase RAB2B and its effector protein Golgi-associated RAB2B interactor-like 5 (GARIL5) in the cGAS-mediated IFN response. RAB2B-deficiency affects the IFN response induced by cytosolic DNA. Consistent with this, RAB2B-deficiency enhances replication of vaccinia virus, a DNA virus. After DNA stimulation, RAB2B colocalizes with stimulator of interferon genes (STING), the downstream signal mediator of cGAS, on the Golgi apparatus. GTP-binding activity of RAB2B is required for its localization on the Golgi apparatus and for recruitment of GARIL5. GARIL5 deficiency also affects the IFN response induced by cytosolic DNA and enhances replication of vaccinia virus. These findings indicate that the RAB2B-GARIL5 complex promotes IFN responses against DNA viruses by regulating the cGAS-STING signaling axis. äThe RAB2B-GARIL5 complex promotes cytosolic DNA-induced innate immune (epmc).pdf DeepDyve Pubget Overpricing