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http://scihub22266oqcxt.onion/ C5614483!5614483!28838333     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Biol+(Noisy-le-grand) 2017 ; 63 (7): 12-9 Nephropedia Template TP {{tp|p=28838333|t=2017. Hypoxia stimulates neural stem cell proliferation by increasing HIF-1? expression and activating Wnt/?-catenin signaling |pdf=|usr=}}{{28838333}} gab.com Text Hypoxia stimulates neural stem cell proliferation by increasing HIF-1 expression and activating Wnt/ -catenin signaling JO: Cell Mol Biol (Noisy-le-grand) http://www.kidney.de/pget.php?&tw=1&pmid=28838333 #FOAvip Evidence indicates that after brain injury, neurogenesis is enhanced in regions such as hippocampus, striatum, and cortex. To study the role of hypoxia-inducible factor-1 (HIF?1?) and Wnt signaling in cerebral ischemia/hypoxia-induced proliferation of neural stem cells (NSCs), we investigated the proliferation of NSCs, expression of HIF?1?, and activation of Wnt signaling under conditions of pathologic hypoxia in vitro. NSCs were isolated from 30-day-old Sprague?Dawley rats and subjected to 0.3% oxygen in a microaerophilic incubation system. Cell proliferation was evaluated by measuring the diameter of neurospheres and by bromodeoxyuridine incorporation assays. Real-time quantitative PCR and Western blotting were used to detect mRNA and protein levels of HIF-1?, ?-catenin, and cyclin D1 in the NSCs. The results showed that hypoxia increased NSC proliferation and the levels of HIF-1?, ??catenin, and cyclin D1 (p < 0.05). Blockade of the Wnt signaling pathway decreased hypoxia-induced NSC proliferation, whereas activation of this pathway increased hypoxia-induced NSC proliferation (p < 0.05). Knockdown of HIF-1? with HIF-1? siRNA decreased ??catenin nuclear translocation and cyclin D1 expression, and inhibited proliferation of NSCs (p < 0.05). These findings indicate that pathologic hypoxia stimulates NSC proliferation by increasing expression of HIF-1? and activating the Wnt/?-catenin signaling pathway. The data suggest that Wnt/?-catenin signaling may play a key role in NSC proliferation under conditions of pathologic hypoxia. Twit Text FOAVip Hypoxia stimulates neural stem cell proliferation by increasing HIF-1 expression and activating Wnt/ -catenin signaling ????Cell Mol Biol (Noisy-le-grand) http://www.kidney.de/pget.php?&tw=1&pmid=28838333 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28838333 #FOAvip English Wikipedia <ref>{{Cite pmid|28838333}}</ref> Hypoxia stimulates neural stem cell proliferation by increasing HIF-1? expression and activating Wnt/?-catenin signaling #MMPMID28838333 Qi C; Zhang J; Chen X; Wan J; Wang J; Zhang P; Liu Y Cell Mol Biol (Noisy-le-grand) 2017[Aug]; 63 (7): 12-9 PMID28838333show ga Evidence indicates that after brain injury, neurogenesis is enhanced in regions such as hippocampus, striatum, and cortex. To study the role of hypoxia-inducible factor-1 (HIF?1?) and Wnt signaling in cerebral ischemia/hypoxia-induced proliferation of neural stem cells (NSCs), we investigated the proliferation of NSCs, expression of HIF?1?, and activation of Wnt signaling under conditions of pathologic hypoxia in vitro. NSCs were isolated from 30-day-old Sprague?Dawley rats and subjected to 0.3% oxygen in a microaerophilic incubation system. Cell proliferation was evaluated by measuring the diameter of neurospheres and by bromodeoxyuridine incorporation assays. Real-time quantitative PCR and Western blotting were used to detect mRNA and protein levels of HIF-1?, ?-catenin, and cyclin D1 in the NSCs. The results showed that hypoxia increased NSC proliferation and the levels of HIF-1?, ??catenin, and cyclin D1 (p < 0.05). Blockade of the Wnt signaling pathway decreased hypoxia-induced NSC proliferation, whereas activation of this pathway increased hypoxia-induced NSC proliferation (p < 0.05). Knockdown of HIF-1? with HIF-1? siRNA decreased ??catenin nuclear translocation and cyclin D1 expression, and inhibited proliferation of NSCs (p < 0.05). These findings indicate that pathologic hypoxia stimulates NSC proliferation by increasing expression of HIF-1? and activating the Wnt/?-catenin signaling pathway. The data suggest that Wnt/?-catenin signaling may play a key role in NSC proliferation under conditions of pathologic hypoxia. äHypoxia stimulates neural stem cell proliferation by increasing HIF-1?(epmc).pdf DeepDyve Pubget Overpricing