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2017 ; 2017
(ä): 3256542
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English Wikipedia
Management of Psychosis in Parkinson s Disease: Emphasizing Clinical Subtypes and
Pathophysiological Mechanisms of the Condition
#MMPMID29104810
Taddei RN
; Cankaya S
; Dhaliwal S
; Chaudhuri KR
Parkinsons Dis
2017[]; 2017
(ä): 3256542
PMID29104810
show ga
Investigation into neuropsychiatric symptoms in Parkinson's disease (PD) is
sparse and current drug development is mainly focused on the motor aspect of PD.
The tight association of psychosis with an impaired quality of life in PD,
together with an important underreporting of this comorbid condition, contributes
to its actual insufficient assessment and management. Furthermore, the withdrawal
from access to readily available treatment interventions is unacceptable and has
an impact on PD prognosis. Despite its impact, to date no standardized guidelines
to the adequate management of PD psychosis are available and they are therefore
highly needed. Readily available knowledge on distinct clinical features as well
as early biomarkers of psychosis in PD justifies the potential for its timely
diagnosis and for early intervention strategies. Also, its specific
characterisation opens up the possibility of further understanding the underlying
pathophysiological mechanisms giving rise to more targeted therapeutic
developments in the nearer future. A literature review on the most recent
knowledge with special focus on specific clinical subtypes and pathophysiological
mechanisms will not only contribute to an up to date practical approach of this
condition for the health care providers, but furthermore open up new ideas for
research in the near future.