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10.1146/annurev-immunol-051116-052433

http://scihub22266oqcxt.onion/10.1146/annurev-immunol-051116-052433
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C5613280!5613280!28446061
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suck abstract from ncbi

pmid28446061      Annu+Rev+Immunol 2017 ; 35 (ä): 285-311
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  • Signaling by Antibodies: Recent Progress #MMPMID28446061
  • Bournazos S; Wang TT; Dahan R; Maamary J; Ravetch JV
  • Annu Rev Immunol 2017[Apr]; 35 (ä): 285-311 PMID28446061show ga
  • IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through Type I and Type II Fc receptors is required for the control of pro-inflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammation, as well as determine susceptibility to infection and autoimmunity, and responsiveness to antibody-based therapeutics, and vaccine responses.
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