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10.1016/j.bbrep.2016.05.013 http://scihub22266oqcxt.onion/10.1016/j.bbrep.2016.05.013 C5613279!5613279!28955889     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Rep 2016 ; 7 (ä): 56-62 Nephropedia Template TP {{tp|p=28955889|t=2016. Actin exposure upon tissue injury is a targetable wound site-specific protein marker |pdf=|usr=}}{{28955889}} gab.com Text Actin exposure upon tissue injury is a targetable wound site-specific protein marker JO: Biochem Biophys Rep http://www.kidney.de/pget.php?&tw=1&pmid=28955889 #FOAvip Background: Identification of wound-specific markers would represent an important step toward damaged tissue detection and targeted delivery of biologically important materials to injured sites. Such delivery could minimize the amount of therapeutic materials that must be administered and limit potential collateral damage on nearby normal tissues. Yet, biological markers that are specific for injured tissue sites remain elusive. Methods: In this study, we have developed an immunohistological approach for identification of protein epitopes specifically exposed in wounded tissue sites. Results: Using ex-vivo tissue samples in combination with fluorescently-labeled antibodies we show that actin, an intracellular cytoskeletal protein, is specifically exposed upon injury. The targetability of actin in injured sites has been demonstrated in vivo through the specific delivery of anti-actin conjugated particles to the wounded tissue in a lethal rat model of grade IV liver injury. Conclusions: These results illustrate that identification of injury-specific protein markers and their targetability for specific delivery is feasible. General significance: Identification of wound-specific targets has important medical applications as it could enable specific delivery of various products, such as expression vectors, therapeutic drugs, hemostatic materials, tissue healing, or scar prevention agents, to internal sites of penetrating or surgical wounds regardless of origin, geometry or location. Twit Text FOAVip Actin exposure upon tissue injury is a targetable wound site-specific protein marker ????Biochem Biophys Rep http://www.kidney.de/pget.php?&tw=1&pmid=28955889 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28955889 #FOAvip English Wikipedia <ref>{{Cite pmid|28955889}}</ref> Actin exposure upon tissue injury is a targetable wound site-specific protein marker #MMPMID28955889 Pendleton ED; Sullivan CJ; Sasmor HH; Bruse KD; Mayfield TB; Valente DL; Abrams RE; Griffey RH; Dresios J Biochem Biophys Rep 2016[Sep]; 7 (ä): 56-62 PMID28955889show ga Background: Identification of wound-specific markers would represent an important step toward damaged tissue detection and targeted delivery of biologically important materials to injured sites. Such delivery could minimize the amount of therapeutic materials that must be administered and limit potential collateral damage on nearby normal tissues. Yet, biological markers that are specific for injured tissue sites remain elusive. Methods: In this study, we have developed an immunohistological approach for identification of protein epitopes specifically exposed in wounded tissue sites. Results: Using ex-vivo tissue samples in combination with fluorescently-labeled antibodies we show that actin, an intracellular cytoskeletal protein, is specifically exposed upon injury. The targetability of actin in injured sites has been demonstrated in vivo through the specific delivery of anti-actin conjugated particles to the wounded tissue in a lethal rat model of grade IV liver injury. Conclusions: These results illustrate that identification of injury-specific protein markers and their targetability for specific delivery is feasible. General significance: Identification of wound-specific targets has important medical applications as it could enable specific delivery of various products, such as expression vectors, therapeutic drugs, hemostatic materials, tissue healing, or scar prevention agents, to internal sites of penetrating or surgical wounds regardless of origin, geometry or location. äActin exposure upon tissue injury is a targetable wound site-specific (epmc).pdf DeepDyve Pubget Overpricing