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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Biochem+Biophys+Rep
2016 ; 7
(ä): 91-97
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Induction of IL-10-producing regulatory B cells following Toxoplasma gondii
infection is important to the cyst formation
#MMPMID28955894
Jeong YI
; Hong SH
; Cho SH
; Park MY
; Lee SE
Biochem Biophys Rep
2016[Sep]; 7
(ä): 91-97
PMID28955894
show ga
Toxoplasma gondii is a protozoan parasite that infects humans and animals via
congenital or postnatal routes. During parasite infection, IL-10-producing Bregs
are stimulated as part of the parasite-induced host immune responses that favor
infection. In this study, we investigated whether T. gondii infection induces
immune regulatory cells including IL-10-producing CD1d(high)CD5(+) regulatory B
cells (Bregs) and whether Breg induction is critical for the development of
chronic infection of T. gondii. Furthermore, B cell-deficient (?MT) mice revealed
that the IL-10-producing B cells might be associated with the development of
chronic T. gondii infection. To better understand the mechanism underlying the
accumulation of IL-10-producing B cells upon T. gondii infection, we determined
the effect of products released by T. gondii on the induction and differentiation
of IL-10-producing B cells during the acute stage of infection using transgenic
green fluorescent protein (GFP)-expressing T. gondii strain. We demonstrated that
products secreted at the stage of cell lysis by fully replicated tachyzoites
induced the differentiation of naive B cells to IL-10-producing Bregs. Our
results indicated that the downregulation of the immune response via Bregs during
T. gondii infection is related to cyst formation in the host brain and to the
establishment of chronic infection.