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10.1016/j.bbrep.2016.05.008

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suck abstract from ncbi


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pmid28955894
      Biochem+Biophys+Rep 2016 ; 7 (ä): 91-97
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  • Induction of IL-10-producing regulatory B cells following Toxoplasma gondii infection is important to the cyst formation #MMPMID28955894
  • Jeong YI ; Hong SH ; Cho SH ; Park MY ; Lee SE
  • Biochem Biophys Rep 2016[Sep]; 7 (ä): 91-97 PMID28955894 show ga
  • Toxoplasma gondii is a protozoan parasite that infects humans and animals via congenital or postnatal routes. During parasite infection, IL-10-producing Bregs are stimulated as part of the parasite-induced host immune responses that favor infection. In this study, we investigated whether T. gondii infection induces immune regulatory cells including IL-10-producing CD1d(high)CD5(+) regulatory B cells (Bregs) and whether Breg induction is critical for the development of chronic infection of T. gondii. Furthermore, B cell-deficient (?MT) mice revealed that the IL-10-producing B cells might be associated with the development of chronic T. gondii infection. To better understand the mechanism underlying the accumulation of IL-10-producing B cells upon T. gondii infection, we determined the effect of products released by T. gondii on the induction and differentiation of IL-10-producing B cells during the acute stage of infection using transgenic green fluorescent protein (GFP)-expressing T. gondii strain. We demonstrated that products secreted at the stage of cell lysis by fully replicated tachyzoites induced the differentiation of naive B cells to IL-10-producing Bregs. Our results indicated that the downregulation of the immune response via Bregs during T. gondii infection is related to cyst formation in the host brain and to the establishment of chronic infection.
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