Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28955730
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28955730
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Cancer+Metastasis+Treat
2017 ; 3
(ä): 150-160
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
TGF-? Stimulation of EMT Programs Elicits Non-genomic ER-? Activity and
Anti-estrogen Resistance in Breast Cancer Cells
#MMPMID28955730
Tian M
; Schiemann WP
J Cancer Metastasis Treat
2017[]; 3
(ä): 150-160
PMID28955730
show ga
AIM: Estrogen receptor-? (ER-?) activation drives the progression of luminal
breast cancers. Signaling by transforming growth factor-? (TGF-?) typically
opposes the actions of ER-?; it also induces epithelial-mesenchymal transition
(EMT) programs that promote breast cancer dissemination, stemness, and
chemoresistance. The impact of EMT programs on nongenomic ER-? signaling remains
unknown and was studied herein. METHODS: MCF-7 and BT474 cells were stimulated
with TGF-? to induce EMT programs, at which point ER-? expression, localization,
and nongenomic interactions with receptor tyrosine kinases and MAP kinases
(MAPKs) were determined. Cell sensitivity to anti-estrogens both before and after
traversing the EMT program was also investigated. RESULTS: TGF-? stimulated MCF-7
and BT474 cells to acquire EMT phenotypes, which enhanced cytoplasmic
accumulation of ER-? without altering its expression. Post-EMT cells exhibited
(i) elevated expression of EGFR and IGF1R, which together with Src formed
cytoplasmic complexes with ER-?; (ii) enhanced coupling of EGF, IGF-1 and
estrogen to the activation of MAPKs; and (iii) reduced sensitivity to tamoxifen,
an event reversed by administration of small molecule inhibitors against the
receptors for TGF-?, EGF, and IGF-1, as well as those against MAPKs. CONCLUSION:
EMT stimulated by TGF-? promotes anti-estrogen resistance by activating EGFR-,
IGF1R-, and MAPK-dependent nongenomic ER-? signaling.
free
free
free
