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10.1021/acs.biomac.6b00635 http://scihub22266oqcxt.onion/10.1021/acs.biomac.6b00635 C5612378!5612378!27563833     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomacromolecules 2016 ; 17 (10): 3138-44 Nephropedia Template TP {{tp|p=27563833|t=2016. Focused Library Approach to Discover Discrete Dipeptide Bolaamphiphiles for siRNA Delivery |pdf=|usr=}}{{27563833}} gab.com Text Focused Library Approach to Discover Discrete Dipeptide Bolaamphiphiles for siRNA Delivery JO: Biomacromolecules http://www.kidney.de/pget.php?&tw=1&pmid=27563833 #FOAvip In this study, we report a new dipeptide functionalization strategy for developing new dendritic bolaamphiphile vectors for efficient siRNA transfection. A focused library of dipeptides was constructed using four amino acids: l-arginine, l-histidine, l-lysine, and l-tryptophan. The dipeptides were coupled to two dendritic bolaamphiphile scaffolds that we developed previously, allowing us to quickly access a focused library of discrete vectors with multivalent dendritic dipeptide functionalities. The resulting discrete bolaamphiphiles were screened for siRNA delivery in vitro in HEK-293 and HeLa cells. Bolaamphiphiles functionalized with dipeptides containing Lys or Arg and either His or Trp were the most effective for in vitro siRNA delivery. Necessary cationic charge to ensure efficient siRNA binding are provided by Arg and Lys residues, whereas endosomal escape is provided through pH responsive buffering of His or membrane interactions of Trp. The most effective vectors (F10 HR/RH) exhibited greater than 75% gene silencing in multiple cell lines and exhibited serum stability. Twit Text FOAVip Focused Library Approach to Discover Discrete Dipeptide Bolaamphiphiles for siRNA Delivery ????Biomacromolecules http://www.kidney.de/pget.php?&tw=1&pmid=27563833 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27563833 #FOAvip English Wikipedia <ref>{{Cite pmid|27563833}}</ref> Focused Library Approach to Discover Discrete Dipeptide Bolaamphiphiles for siRNA Delivery #MMPMID27563833 Eldredge AC; Johnson ME; Oldenhuis NJ; Guan Z Biomacromolecules 2016[Oct]; 17 (10): 3138-44 PMID27563833show ga In this study, we report a new dipeptide functionalization strategy for developing new dendritic bolaamphiphile vectors for efficient siRNA transfection. A focused library of dipeptides was constructed using four amino acids: l-arginine, l-histidine, l-lysine, and l-tryptophan. The dipeptides were coupled to two dendritic bolaamphiphile scaffolds that we developed previously, allowing us to quickly access a focused library of discrete vectors with multivalent dendritic dipeptide functionalities. The resulting discrete bolaamphiphiles were screened for siRNA delivery in vitro in HEK-293 and HeLa cells. Bolaamphiphiles functionalized with dipeptides containing Lys or Arg and either His or Trp were the most effective for in vitro siRNA delivery. Necessary cationic charge to ensure efficient siRNA binding are provided by Arg and Lys residues, whereas endosomal escape is provided through pH responsive buffering of His or membrane interactions of Trp. The most effective vectors (F10 HR/RH) exhibited greater than 75% gene silencing in multiple cell lines and exhibited serum stability. äFocused Library Approach to Discover Discrete Dipeptide Bolaamphiphile(epmc).pdf DeepDyve Pubget Overpricing