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10.1053/j.seminoncol.2017.06.002 http://scihub22266oqcxt.onion/10.1053/j.seminoncol.2017.06.002 C5612055!5612055 !28923212     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28923212 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Semin+Oncol 2017 ; 44 (2 ): 136-140 Nephropedia Template TP {{tp|p=28923212 |t=2017. A molecular and preclinical comparison of the PD-1-targeted T-cell checkpoint inhibitors nivolumab and pembrolizumab |pdf=|usr=}}{{28923212 }} gab.com Text A molecular and preclinical comparison of the PD-1-targeted T-cell checkpoint inhibitors nivolumab and pembrolizumab JO: Semin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28923212 #FOAvip T-cell checkpoint inhibition has a profound impact on cancer care and the programmed cell death protein 1 (PD-1)-targeted antibodies nivolumab and pembrolizumab have been two of the lead molecules of this therapeutic revolution. Their clinical comparability is a highly relevant topic of discussion, but to a significant degree is a consequence of their molecular properties. Here we provide a molecular, preclinical, and early clinical comparison of the two antibodies, based on the available data and recent literature. We acknowledge the limitations of such comparisons, but suggest that based on the available data, differences in clinical trial outcomes between nivolumab and pembrolizumab are more likely drug-independent than drug-dependent. Twit Text FOAVip A molecular and preclinical comparison of the PD-1-targeted T-cell checkpoint inhibitors nivolumab and pembrolizumab ????Semin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28923212 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28923212 #FOAvip English Wikipedia <ref>{{Cite pmid|28923212 }}</ref> A molecular and preclinical comparison of the PD-1-targeted T-cell checkpoint inhibitors nivolumab and pembrolizumab #MMPMID28923212 Fessas P ; Lee H ; Ikemizu S ; Janowitz T Semin Oncol 2017[Apr]; 44 (2 ): 136-140 PMID28923212 show ga T-cell checkpoint inhibition has a profound impact on cancer care and the programmed cell death protein 1 (PD-1)-targeted antibodies nivolumab and pembrolizumab have been two of the lead molecules of this therapeutic revolution. Their clinical comparability is a highly relevant topic of discussion, but to a significant degree is a consequence of their molecular properties. Here we provide a molecular, preclinical, and early clinical comparison of the two antibodies, based on the available data and recent literature. We acknowledge the limitations of such comparisons, but suggest that based on the available data, differences in clinical trial outcomes between nivolumab and pembrolizumab are more likely drug-independent than drug-dependent. |Animals [MESH] |Antibodies, Monoclonal, Humanized/chemistry/*pharmacology [MESH] |Antibodies, Monoclonal/chemistry/*pharmacology [MESH] |Antineoplastic Agents/chemistry/*pharmacology [MESH] |Humans [MESH] |Lymphocyte Activation/drug effects [MESH] |Molecular Structure [MESH] |Nivolumab [MESH] |Programmed Cell Death 1 Receptor/*antagonists & inhibitors/chemistry [MESH]A molecular and preclinical comparison of the PD-1-targeted T-cell che(epmc).pdf DeepDyve Pubget Overpricing