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10.1016/j.celrep.2017.08.060 http://scihub22266oqcxt.onion/10.1016/j.celrep.2017.08.060 C5611819!5611819!28903040     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2017 ; 20 (11): 2584-97 Nephropedia Template TP {{tp|p=28903040|t=2017. MiR-150 regulates memory CD8 T cell differentiation via c-Myb |pdf=|usr=}}{{28903040}} gab.com Text MiR-150 regulates memory CD8 T cell differentiation via c-Myb JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28903040 #FOAvip MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells following acute viral infection. Moreover, miR-150-deficient memory CD8 T cells were more protective upon rechallenge. A key circuit whereby miR-150 repressed memory CD8 T cell development through the transcription factor c-Myb was identified. Without miR-150, c-Myb was upregulated and anti-apoptotic targets of c-Myb such as Bcl-2 and Bcl-xL were also increased suggesting a miR-150-c-Myb survival circuit during memory CD8 T cell development. Indeed, overexpression of non-repressible c-Myb rescued the memory CD8 T cell defects caused by overexpression of miR-150. Overall, these results identify a key role for miR-150 in memory CD8 T cells through a c-Myb-controlled enhanced survival circuit. Twit Text FOAVip MiR-150 regulates memory CD8 T cell differentiation via c-Myb ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28903040 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28903040 #FOAvip English Wikipedia <ref>{{Cite pmid|28903040}}</ref> MiR-150 regulates memory CD8 T cell differentiation via c-Myb #MMPMID28903040 Chen Z; Stelekati E; Kurachi M; Yu S; Cai Z; Manne S; Khan O; Yang X; Wherry EJ Cell Rep 2017[Sep]; 20 (11): 2584-97 PMID28903040show ga MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells following acute viral infection. Moreover, miR-150-deficient memory CD8 T cells were more protective upon rechallenge. A key circuit whereby miR-150 repressed memory CD8 T cell development through the transcription factor c-Myb was identified. Without miR-150, c-Myb was upregulated and anti-apoptotic targets of c-Myb such as Bcl-2 and Bcl-xL were also increased suggesting a miR-150-c-Myb survival circuit during memory CD8 T cell development. Indeed, overexpression of non-repressible c-Myb rescued the memory CD8 T cell defects caused by overexpression of miR-150. Overall, these results identify a key role for miR-150 in memory CD8 T cells through a c-Myb-controlled enhanced survival circuit. äMiR-150 regulates memory CD8 T cell differentiation via c-Myb (epmc).pdf DeepDyve Pubget Overpricing