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10.21873/cgp.20040 http://scihub22266oqcxt.onion/10.21873/cgp.20040 C5611516!5611516!28870997     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Genomics+Proteomics 2017 ; 14 (5): 293-8 Nephropedia Template TP {{tp|p=28870997|t=2017. The Evolution, Functions and Applications of the Breast Cancer Genes BRCA1 and BRCA2 |pdf=|usr=}}{{28870997}} gab.com Text The Evolution, Functions and Applications of the Breast Cancer Genes BRCA1 and BRCA2 JO: Cancer Genomics Proteomics http://www.kidney.de/pget.php?&tw=1&pmid=28870997 #FOAvip BRCA1 and BRCA2 are both tumor suppressors whose mutations are the cause of most hereditary breast cancers. Both genes are highly involved in ensuring genome stability. BRCA1 homologs are found in the plant and animal kingdoms while BRCA2 homologs are additionally found in the fungi kingdom. The initial origin of both genes remains unknown, however it is expected that the common ancestors originated around 1.6 billion years ago prior to the kingdoms diverging. There has been a great amount of divergence between homologs that is not observed in other tumor suppressors with only functionally important domains conserved. This divergence continues today with evidence of primate BRCA1/2 evolution. Cancer-associated mutations have been found to occur at conserved sites, indicating that conserved sites are important for function. In this study, we present a review on the phylogenesis of BRCA1 and BRCA2. Twit Text FOAVip The Evolution, Functions and Applications of the Breast Cancer Genes BRCA1 and BRCA2 ????Cancer Genomics Proteomics http://www.kidney.de/pget.php?&tw=1&pmid=28870997 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28870997 #FOAvip English Wikipedia <ref>{{Cite pmid|28870997}}</ref> The Evolution, Functions and Applications of the Breast Cancer Genes BRCA1 and BRCA2 #MMPMID28870997 PFEFFER MC; HO NB; SINGH TA Cancer Genomics Proteomics 2017[Sep]; 14 (5): 293-8 PMID28870997show ga BRCA1 and BRCA2 are both tumor suppressors whose mutations are the cause of most hereditary breast cancers. Both genes are highly involved in ensuring genome stability. BRCA1 homologs are found in the plant and animal kingdoms while BRCA2 homologs are additionally found in the fungi kingdom. The initial origin of both genes remains unknown, however it is expected that the common ancestors originated around 1.6 billion years ago prior to the kingdoms diverging. There has been a great amount of divergence between homologs that is not observed in other tumor suppressors with only functionally important domains conserved. This divergence continues today with evidence of primate BRCA1/2 evolution. Cancer-associated mutations have been found to occur at conserved sites, indicating that conserved sites are important for function. In this study, we present a review on the phylogenesis of BRCA1 and BRCA2. äThe Evolution, Functions and Applications of the Breast Cancer Genes B(epmc).pdf DeepDyve Pubget Overpricing