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2017 ; 60
(3
): 135-144
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Ultrasound Assessment of Kidney Volume in Patients with Acute Decompensated Heart
Failure: A Predictor of Diuretic Resistance
#MMPMID28959123
Sugihara S
; Kinugasa Y
; Takata T
; Sugihara T
; Hosho K
; Imai C
; Ito H
; Yamada K
; Kato M
; Yamamoto K
Yonago Acta Med
2017[Sep]; 60
(3
): 135-144
PMID28959123
show ga
BACKGROUND: Diuretics are essential for treating acute decompensated heart
failure (ADHF), but the response is inconsistent. This study aimed to clarify
whether kidney volume as assessed by ultrasound (US) predicts diuretic resistance
in patients with ADHF. METHODS: We enrolled 29 patients with ADHF and 32
controls. Height-adjusted kidney volume was assessed by US. We divided patients
into two groups based on the median value of total daily use of furosemide
(intravenous dose plus 0.5 × oral dose of furosemide equivalents) during 3 days
from admission. RESULTS: Patients with ADHF had a significantly smaller left
kidney volume than did control subjects (27.7 ± 10.0 vs. 32.8 ± 8.8 mL/m, P <
0.05). Patients in the high-dose furosemide group (? 51.7 mg/d) had a
significantly lower estimated glomerular filtration rate (eGFR) and a
significantly smaller kidney volume than did those in the low-dose furosemide
group (eGFR: 43.9 ± 20.4 vs. 60.8 ± 21.6 mL/min/1.73 m(2), left kidney volume:
23.2 ± 5.2 vs. 32.6 ± 11.0 mL/m, right kidney volume: 26.5 ± 7.5 vs. 32.6 ± 7.9
mL/m, all P < 0.05). Multivariate logistic analysis showed that left kidney
volume, but not eGFR, was independently associated with the requirement of
high-dose furosemide (odds ratio: 0.856, 95% confidence interval: 0.735-0.997, P
< 0.05). CONCLUSION: Kidney volume as assessed by US is a useful predictor of
diuretic resistance in patients with ADHF.