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10.1189/jlb.4HI0316-157R http://scihub22266oqcxt.onion/10.1189/jlb.4HI0316-157R C5610570!5610570 !27468760     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27468760 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Leukoc+Biol 2017 ; 101 (2 ): 367-376 Nephropedia Template TP {{tp|p=27468760 |t=2017. Frontline Science: Coincidental null mutation of Csf2r? in a colony of PI3K?-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection |pdf=|usr=}}{{27468760 }} gab.com Text Frontline Science: Coincidental null mutation of Csf2r in a colony of PI3K -/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=27468760 #FOAvip PI3Ks have been identified as key signaling proteins involved in many basic biologic processes in health and disease. Transgenic animals have been essential tools to study the underlying molecular mechanisms in this context and therefore, have been widely used to elucidate the role of these factors in many different settings. More specifically, PI3K?, a subunit highly expressed in the hematopoietic system, has been implicated to play an important role in many inflammatory diseases as well as cancer. Here, we report identification of multiple, additional, previously unknown mutations in the genome of a widely used PI3K?-deficient (PI3K?(-/-)) mouse colony. These include a STOP mutation in the GM-CSFR? chain, leading to a complete and specific deficiency in GM-CSF signaling. PI3K?(-/-) animals consequently lacked alveolar macrophages (AMs) and succumbed rapidly to influenza virus infection. Furthermore, PI3K?(-/-) mice carried an additional mutation that affects mucin 2 (Muc2) transcripts. This protein is strongly involved in the regulation of colorectal cancer, and indeed, conflicting reports have indicated that PI3K?(-/-) animals spontaneously develop colorectal tumors. Thus, we uncover previously unknown, confounding factors present in a strain of PI3K?(-/-) mice, leading to additional deficiencies in important signaling pathways with potentially wide-ranging implications for the interpretation of previous studies. By separating the mutations, we established a unique Csf2ra(-/-) mouse model that allows us to study the role of cell intrinsic GM-CSFR signaling in vivo without confounding variables introduced by defective IL-5R and IL-3R signaling in mice lacking the common ? chain (Csf2rb). Twit Text FOAVip Frontline Science: Coincidental null mutation of Csf2r in a colony of PI3K -/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=27468760 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27468760 #FOAvip English Wikipedia <ref>{{Cite pmid|27468760 }}</ref> Frontline Science: Coincidental null mutation of Csf2r? in a colony of PI3K?-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection #MMPMID27468760 Schneider C ; Nobs SP ; Heer AK ; Hirsch E ; Penninger J ; Siggs OM ; Kopf M J Leukoc Biol 2017[Feb]; 101 (2 ): 367-376 PMID27468760 show ga PI3Ks have been identified as key signaling proteins involved in many basic biologic processes in health and disease. Transgenic animals have been essential tools to study the underlying molecular mechanisms in this context and therefore, have been widely used to elucidate the role of these factors in many different settings. More specifically, PI3K?, a subunit highly expressed in the hematopoietic system, has been implicated to play an important role in many inflammatory diseases as well as cancer. Here, we report identification of multiple, additional, previously unknown mutations in the genome of a widely used PI3K?-deficient (PI3K?(-/-)) mouse colony. These include a STOP mutation in the GM-CSFR? chain, leading to a complete and specific deficiency in GM-CSF signaling. PI3K?(-/-) animals consequently lacked alveolar macrophages (AMs) and succumbed rapidly to influenza virus infection. Furthermore, PI3K?(-/-) mice carried an additional mutation that affects mucin 2 (Muc2) transcripts. This protein is strongly involved in the regulation of colorectal cancer, and indeed, conflicting reports have indicated that PI3K?(-/-) animals spontaneously develop colorectal tumors. Thus, we uncover previously unknown, confounding factors present in a strain of PI3K?(-/-) mice, leading to additional deficiencies in important signaling pathways with potentially wide-ranging implications for the interpretation of previous studies. By separating the mutations, we established a unique Csf2ra(-/-) mouse model that allows us to study the role of cell intrinsic GM-CSFR signaling in vivo without confounding variables introduced by defective IL-5R and IL-3R signaling in mice lacking the common ? chain (Csf2rb). |Animals [MESH] |Class Ib Phosphatidylinositol 3-Kinase/deficiency/metabolism [MESH] |Crosses, Genetic [MESH] |Disease Susceptibility [MESH] |Female [MESH] |Granulocyte-Macrophage Colony-Stimulating Factor [MESH] |Macrophages, Alveolar/*metabolism/pathology [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mutation/*genetics [MESH] |Orthomyxoviridae Infections/pathology/virology [MESH] |Orthomyxoviridae/physiology [MESH] |Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/*genetics/metabolism [MESH] |Respiratory Tract Diseases/*genetics/pathology/*virology [MESH]Frontline Science: Coincidental null mutation of Csf2r? in a colony of(epmc).pdf DeepDyve Pubget Overpricing