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10.18632/oncotarget.19451 http://scihub22266oqcxt.onion/10.18632/oncotarget.19451 C5609997/?report=reader!5609997!28969065     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (38): 64224-36 Nephropedia Template TP {{tp|p=28969065|t=2017. MRGBP as a potential biomarker for the malignancy of pancreatic ductal adenocarcinoma |pdf=|usr=}}{{28969065}} gab.com Text MRGBP as a potential biomarker for the malignancy of pancreatic ductal adenocarcinoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28969065 #FOAvip MORF4-related gene-binding protein (MRGBP), which is also known as chromosome 20 open reading frame 20 (C20orf20), is commonly highly expressed in several types of malignant tumors and tumor progression. However, the expression pattern and underlying mechanism of MRGBP in pancreatic ductal adenocarcinoma (PDAC) remain unknown. In the study, we found that MRGBP was frequently upregulated in PDAC tissues and cell lines. In addition, the upregulation of MRGBP was positively associated with TNM stage, T classification, and poor prognosis. Knockdown of MRGBP in the PDAC cell lines ASPC-1 and Mia PaCa-2 by transiently transfected with small interfering RNA (siRNA) drastically attenuated the proliferation, migration, and invasion of those cells, whereas ectopic MRGBP overexpression in BxPC-3 cells produced exactly the opposite effect. Furthermore, we also found that overexpression of MRGBP remarkably led to cell morphological changes and induced an increased expression of mesenchymal marker Vimentin, whereas a decreased expression of epithelial marker E-cadherin. Taken together, this study indicates that MRGBP acts as a tumor oncogene in PDAC and is a promising target of carcinogenesis. Twit Text FOAVip MRGBP as a potential biomarker for the malignancy of pancreatic ductal adenocarcinoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28969065 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28969065 #FOAvip English Wikipedia <ref>{{Cite pmid|28969065}}</ref> MRGBP as a potential biomarker for the malignancy of pancreatic ductal adenocarcinoma #MMPMID28969065 Ding F; Zhang S; Gao S; Shang J; Li Y; Cui N; Zhao Q Oncotarget 2017[Sep]; 8 (38): 64224-36 PMID28969065show ga MORF4-related gene-binding protein (MRGBP), which is also known as chromosome 20 open reading frame 20 (C20orf20), is commonly highly expressed in several types of malignant tumors and tumor progression. However, the expression pattern and underlying mechanism of MRGBP in pancreatic ductal adenocarcinoma (PDAC) remain unknown. In the study, we found that MRGBP was frequently upregulated in PDAC tissues and cell lines. In addition, the upregulation of MRGBP was positively associated with TNM stage, T classification, and poor prognosis. Knockdown of MRGBP in the PDAC cell lines ASPC-1 and Mia PaCa-2 by transiently transfected with small interfering RNA (siRNA) drastically attenuated the proliferation, migration, and invasion of those cells, whereas ectopic MRGBP overexpression in BxPC-3 cells produced exactly the opposite effect. Furthermore, we also found that overexpression of MRGBP remarkably led to cell morphological changes and induced an increased expression of mesenchymal marker Vimentin, whereas a decreased expression of epithelial marker E-cadherin. Taken together, this study indicates that MRGBP acts as a tumor oncogene in PDAC and is a promising target of carcinogenesis. äMRGBP as a potential biomarker for the malignancy of pancreatic ductal(epmc).pdf DeepDyve Pubget Overpricing