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10.18632/oncotarget.19070 http://scihub22266oqcxt.onion/10.18632/oncotarget.19070 C5609960/?report=reader!5609960!28969028     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (38): 63780-7 Nephropedia Template TP {{tp|p=28969028|t=2017. Cytosine 5-hydroxymethylation regulates VHL gene expression in renal clear cell carcinoma |pdf=|usr=}}{{28969028}} gab.com Text Cytosine 5-hydroxymethylation regulates VHL gene expression in renal clear cell carcinoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28969028 #FOAvip Cytosine5-hyxymethylation (5hmC)which is a new epigenetic modification form plays important roles in the development and progression of tumors. In the present study, we observed that levels of 5hmC in the promoter region of Von Hippel-Lindau (VHL) were lower in 97 samples of renal clear cell carcinoma tissue than in matched adjacent benign tissues. Moreover, when the cancer tissue samples were divided based on pathological staging, VHL expression and the level of 5hmC in the VHL promoter were both lower in pathological grade III tumors than in grades I or II. Correspondingly, expression of TET1, which catalyzes the formation of 5hmC, was also lower in grade III renal clear cell carcinomas than in grade I or II disease. These findings suggest the 5hmC level on VHL is a key determinant of the gene's expression and may participate in the occurrence and development of renal clear cell carcinoma. Thus the 5hmC level may be a useful indicator for early diagnosis and appropriate treatment of renal clear cell carcinoma. Twit Text FOAVip Cytosine 5-hydroxymethylation regulates VHL gene expression in renal clear cell carcinoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28969028 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28969028 #FOAvip English Wikipedia <ref>{{Cite pmid|28969028}}</ref> Cytosine 5-hydroxymethylation regulates VHL gene expression in renal clear cell carcinoma #MMPMID28969028 Ma EG; Bai YF; Cao W; Cao Y; Huang YG; Cheng HC; An RH Oncotarget 2017[Sep]; 8 (38): 63780-7 PMID28969028show ga Cytosine5-hyxymethylation (5hmC)which is a new epigenetic modification form plays important roles in the development and progression of tumors. In the present study, we observed that levels of 5hmC in the promoter region of Von Hippel-Lindau (VHL) were lower in 97 samples of renal clear cell carcinoma tissue than in matched adjacent benign tissues. Moreover, when the cancer tissue samples were divided based on pathological staging, VHL expression and the level of 5hmC in the VHL promoter were both lower in pathological grade III tumors than in grades I or II. Correspondingly, expression of TET1, which catalyzes the formation of 5hmC, was also lower in grade III renal clear cell carcinomas than in grade I or II disease. These findings suggest the 5hmC level on VHL is a key determinant of the gene's expression and may participate in the occurrence and development of renal clear cell carcinoma. Thus the 5hmC level may be a useful indicator for early diagnosis and appropriate treatment of renal clear cell carcinoma. äCytosine 5-hydroxymethylation regulates VHL gene expression in renal c(epmc).pdf DeepDyve Pubget Overpricing