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10.1038/ni.3196 http://scihub22266oqcxt.onion/10.1038/ni.3196 C5609676!5609676 !26030023     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26030023 &cmd=llinks): Failed to open stream: HTTP request failed! 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The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways |pdf=|usr=}}{{26030023 }} gab.com Text The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26030023 #FOAvip Dendritic cells (DCs) can initiate immune responses by presenting exogenous antigens to T cells via both major histocompatibility complex (MHC) class I pathways and MHC class II pathways. Lysosomal activity has an important role in modulating the balance between these two pathways. The transcription factor TFEB regulates lysosomal function by inducing lysosomal activation. Here we report that TFEB expression inhibited the presentation of exogenous antigen by MHC class I while enhancing presentation via MHC class II. TFEB promoted phagosomal acidification and protein degradation. Furthermore, we found that the activation of TFEB was regulated during DC maturation and that phagosomal acidification was impaired in DCs in which the gene encoding TFEB was silenced. Our data indicate that TFEB is a key participant in the differential regulation of the presentation of exogenous antigens by DCs. Twit Text FOAVip The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26030023 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26030023 #FOAvip English Wikipedia <ref>{{Cite pmid|26030023 }}</ref> The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways #MMPMID26030023 Samie M ; Cresswell P Nat Immunol 2015[Jul]; 16 (7 ): 729-36 PMID26030023 show ga Dendritic cells (DCs) can initiate immune responses by presenting exogenous antigens to T cells via both major histocompatibility complex (MHC) class I pathways and MHC class II pathways. Lysosomal activity has an important role in modulating the balance between these two pathways. The transcription factor TFEB regulates lysosomal function by inducing lysosomal activation. Here we report that TFEB expression inhibited the presentation of exogenous antigen by MHC class I while enhancing presentation via MHC class II. TFEB promoted phagosomal acidification and protein degradation. Furthermore, we found that the activation of TFEB was regulated during DC maturation and that phagosomal acidification was impaired in DCs in which the gene encoding TFEB was silenced. Our data indicate that TFEB is a key participant in the differential regulation of the presentation of exogenous antigens by DCs. |Animals [MESH] |Antigen Presentation/*immunology [MESH] |Antigens/*immunology [MESH] |Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics/*immunology/metabolism [MESH] |Cells, Cultured [MESH] |Chlorocebus aethiops [MESH] |Cross-Priming/immunology [MESH] |Flow Cytometry [MESH] |HEK293 Cells [MESH] |Histocompatibility Antigens Class II/immunology [MESH] |Humans [MESH] |Hydrogen-Ion Concentration [MESH] |Mice, Inbred C57BL [MESH] |Microscopy, Confocal [MESH] |Phagosomes/immunology/metabolism [MESH] |Proteolysis [MESH] |RNA Interference/immunology [MESH] |Signal Transduction/*immunology [MESH] |Spleen/cytology/immunology/metabolism [MESH]The transcription factor TFEB acts as a molecular switch that regulate(epmc).pdf DeepDyve Pubget Overpricing