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2017 ; 8
(ä): 65
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Comparison of Interleukin-33 Serum Levels in Asthmatic Patients with a Control
Group and Relation with the Severity of the Disease
#MMPMID28966754
Momen T
; Ahanchian H
; Reisi M
; Shamsdin SA
; Shahsanai A
; Keivanfar M
Int J Prev Med
2017[]; 8
(ä): 65
PMID28966754
show ga
BACKGROUND: The relation between interleukin-33 (IL-33) and asthma is not
precisely known yet. The present study set to compare the serum level of IL-33 in
patients with asthma and controls and study the relation with the severity of
disease. METHODS: The serum level of IL-33 and total IgE in 89 asthmatic patients
and 57 controls were analyzed. The association of levels of IL-33 with the
severity of disease, levels of total IgE, measures of spirometry (forced
expiratory volume in 1 s [FEV1]), age, sex, presence or absence of other allergic
diseases, and the disease duration was evaluated. RESULTS: Higher levels of IL-33
and total IgE were detected in asthmatic patients compared with controls (P =
0.0001 and P = 0.008, respectively). In the asthmatic group, a significant direct
association of IL-33 with age (P = 0.02, R = 0.23) and with total IgE level (P =
0.003, R = 0.31) were observed, but there was no relationship between other
variables. Comparison of mean level of IL-33 in different asthma groups
concerning the disease severity showed the statistically significant difference
between them and a significant increased serum level of total IgE was observed in
more severe disease. The results showed a significant negative correlation
between FEV1 and total IgE (P = 0.028, R = -0.23) and IL-33 level (P = 0.0001, R
= -0.83). CONCLUSIONS: IL-33 is suggested as a new inflammatory marker of severe
and refractory asthma. Therefore, it may be a unique therapeutic target in these
patients.