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Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Exp+Ther+Med 2017 ; 14 (3): 2543-53 Nephropedia Template TP
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Doxazosin attenuates renal matrix remodeling mediated by anti-?1-adrenergic receptor antibody in a rat model of diabetes mellitus #MMPMID28962193
Zhao LS; Lin YY; Liu Y; Xu CY; Liu Y; Bai WW; Tan XY; Li DZ; Xu JL
Exp Ther Med 2017[Sep]; 14 (3): 2543-53 PMID28962193show ga
Diabetic nephropathy is a major complication of diabetes mellitus (DM). Recent studies suggest that immunological mechanisms have a key role in the pathogenesis of DM, therefore these mechanisms may be important targets for diabetes therapy. The present study evaluated the effects of anti-?1-adrenergic receptor antibody (?1-R Ab) mediation and doxazosin treatment in a rat model of DM. It was observed that levels of 24-h urinary protein, serum creatinine and transforming growth factor-?1 in DM were significantly increased after ?1-R Ab mediation (all P<0.05). In addition, electron microscopy identified severe damage in the renal tissue microstructures of DM rats following ?1-R Ab mediation, while only mild abnormalities were observed in that of healthy rats mediated with ?1-R Ab and of untreated DM rats. No marked abnormalities were observed in the renal tissue of healthy blank controls. Furthermore, in DM rats treated with ?1-R Ab mediation + doxazosin intervention, the expression of TGF-?1 significantly decreased, and renal functions and renal matrix remodeling were significantly improved, relative to untreated DM controls (P<0.01). These results suggest that ?1-R Ab may be involved in renal matrix remodeling during DM, and that kidney protection during DM may be achieved through treatment with corresponding receptor antagonists.