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10.1038/oncsis.2017.72 http://scihub22266oqcxt.onion/10.1038/oncsis.2017.72 C5608920!5608920!28846078     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogenesis 2017 ; 6 (8): e373- Nephropedia Template TP {{tp|p=28846078|t=2017. Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers |pdf=|usr=}}{{28846078}} gab.com Text Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers JO: Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=28846078 #FOAvip The unfolded protein response (UPR) is an adaptive cellular program used by eukaryotic cells to cope with protein misfolding stress. During tumor development, cancer cells are facing intrinsic (oncogene activation) and extrinsic (limiting nutrient or oxygen supply) challenges, with which they must cope to survive. Moreover, chemotherapy represents an additional extrinsic challenge that cancer cells are facing and to which they adapt in the case of resistance. As of today, resistance to chemotherapy and targeted therapies is one of the important issues that oncologists have to deal with for treating cancer patients. In this review, we first describe the key molecular mechanisms controlling the UPR and their implication in solid cancers. Then, we review the literature that connects cancer chemotherapy resistance mechanisms and activation of the UPR. Finally, we discuss the possible applications of targeting the UPR to bypass drug resistance. Twit Text FOAVip Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers ????Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=28846078 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28846078 #FOAvip English Wikipedia <ref>{{Cite pmid|28846078}}</ref> Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers #MMPMID28846078 Avril T; Vauléon E; Chevet E Oncogenesis 2017[Aug]; 6 (8): e373- PMID28846078show ga The unfolded protein response (UPR) is an adaptive cellular program used by eukaryotic cells to cope with protein misfolding stress. During tumor development, cancer cells are facing intrinsic (oncogene activation) and extrinsic (limiting nutrient or oxygen supply) challenges, with which they must cope to survive. Moreover, chemotherapy represents an additional extrinsic challenge that cancer cells are facing and to which they adapt in the case of resistance. As of today, resistance to chemotherapy and targeted therapies is one of the important issues that oncologists have to deal with for treating cancer patients. In this review, we first describe the key molecular mechanisms controlling the UPR and their implication in solid cancers. Then, we review the literature that connects cancer chemotherapy resistance mechanisms and activation of the UPR. Finally, we discuss the possible applications of targeting the UPR to bypass drug resistance. äEndoplasmic reticulum stress signaling and chemotherapy resistance in (epmc).pdf DeepDyve Pubget Overpricing