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10.1038/s41467-017-00799-8 http://scihub22266oqcxt.onion/10.1038/s41467-017-00799-8 C5608754!5608754!28935898     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28935898|t=2017. PD-L1 is an activation-independent marker of brown adipocytes |pdf=|usr=}}{{28935898}} gab.com Text PD-L1 is an activation-independent marker of brown adipocytes JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28935898 #FOAvip Programmed death ligand 1 (PD-L1) is expressed on a number of immune and cancer cells, where it can downregulate antitumor immune responses. Its expression has been linked to metabolic changes in these cells. Here we develop a radiolabeled camelid single-domain antibody (anti-PD-L1 VHH) to track PD-L1 expression by immuno-positron emission tomography (PET). PET-CT imaging shows a robust and specific PD-L1 signal in brown adipose tissue (BAT). We confirm expression of PD-L1 on brown adipocytes and demonstrate that signal intensity does not change in response to cold exposure or ?-adrenergic activation. This is the first robust method of visualizing murine brown fat independent of its activation state. Twit Text FOAVip PD-L1 is an activation-independent marker of brown adipocytes ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28935898 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28935898 #FOAvip English Wikipedia <ref>{{Cite pmid|28935898}}</ref> PD-L1 is an activation-independent marker of brown adipocytes #MMPMID28935898 Ingram JR; Dougan M; Rashidian M; Knoll M; Keliher EJ; Garrett S; Garforth S; Blomberg OS; Espinosa C; Bhan A; Almo SC; Weissleder R; Lodish H; Dougan SK; Ploegh HL Nat Commun 2017[]; 8 (ä): ä PMID28935898show ga Programmed death ligand 1 (PD-L1) is expressed on a number of immune and cancer cells, where it can downregulate antitumor immune responses. Its expression has been linked to metabolic changes in these cells. Here we develop a radiolabeled camelid single-domain antibody (anti-PD-L1 VHH) to track PD-L1 expression by immuno-positron emission tomography (PET). PET-CT imaging shows a robust and specific PD-L1 signal in brown adipose tissue (BAT). We confirm expression of PD-L1 on brown adipocytes and demonstrate that signal intensity does not change in response to cold exposure or ?-adrenergic activation. This is the first robust method of visualizing murine brown fat independent of its activation state. äPD-L1 is an activation-independent marker of brown adipocytes (epmc).pdf DeepDyve Pubget Overpricing