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10.1038/ni.3813 http://scihub22266oqcxt.onion/10.1038/ni.3813 C5608079!5608079!28805811     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2017 ; 18 (10): 1150-9 Nephropedia Template TP {{tp|p=28805811|t=2017. Caveolin-1-dependent BCR nanoscale organization regulates B cell tolerance |pdf=|usr=}}{{28805811}} gab.com Text Caveolin-1-dependent BCR nanoscale organization regulates B cell tolerance JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28805811 #FOAvip Caveolin-1 (Cav1) regulates plasma membrane nano-organization and compartmentalization. Here, we demonstrate that Cav1 controlled the distribution of immunoglobulin M (IgM)- and IgD- B cell antigen receptor (BCR) nanoclusters on the surface of B cells. In mature B cells, the IgM-BCR gained access to GM1-enriched lipid domains upon antigen stimulation by a process that was dependent on Cav1 phosphorylation by Src family kinases, thereby regulating BCR signaling in vivo. In Cav1?/? immature B cells, altered IgM-BCR nanoscale organization resulted in a failure of receptor editing, and a skewed repertoire of B cells expressing ? heavy chains (HCs) with hallmarks of poly- and auto-reactivity, which ultimately led to autoimmunity in mice. Thus, Cav1 emerges as a cell-intrinsic regulator that prevents B cell-induced autoimmunity by means of its role in plasma membrane organization. Twit Text FOAVip Caveolin-1-dependent BCR nanoscale organization regulates B cell tolerance ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28805811 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28805811 #FOAvip English Wikipedia <ref>{{Cite pmid|28805811}}</ref> Caveolin-1-dependent BCR nanoscale organization regulates B cell tolerance #MMPMID28805811 Minguet S; Kläsener K; Schaffer AM; Fiala GJ; Osteso-Ibánez T; Raute K; Navarro-Lérida I; Hartl FA; Seidl M; Reth M; Del Pozo MA Nat Immunol 2017[Oct]; 18 (10): 1150-9 PMID28805811show ga Caveolin-1 (Cav1) regulates plasma membrane nano-organization and compartmentalization. Here, we demonstrate that Cav1 controlled the distribution of immunoglobulin M (IgM)- and IgD- B cell antigen receptor (BCR) nanoclusters on the surface of B cells. In mature B cells, the IgM-BCR gained access to GM1-enriched lipid domains upon antigen stimulation by a process that was dependent on Cav1 phosphorylation by Src family kinases, thereby regulating BCR signaling in vivo. In Cav1?/? immature B cells, altered IgM-BCR nanoscale organization resulted in a failure of receptor editing, and a skewed repertoire of B cells expressing ? heavy chains (HCs) with hallmarks of poly- and auto-reactivity, which ultimately led to autoimmunity in mice. Thus, Cav1 emerges as a cell-intrinsic regulator that prevents B cell-induced autoimmunity by means of its role in plasma membrane organization. äCaveolin-1-dependent BCR nanoscale organization regulates B cell toler(epmc).pdf DeepDyve Pubget Overpricing