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10.1128/IAI.00004-17 http://scihub22266oqcxt.onion/10.1128/IAI.00004-17 C5607427!5607427!28717031     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Infect+Immun 2017 ; 85 (10): ä Nephropedia Template TP {{tp|p=28717031|t=2017. Phagocytic Receptors Activate Syk and Src Signaling during Borrelia burgdorferi Phagocytosis |pdf=|usr=}}{{28717031}} gab.com Text Phagocytic Receptors Activate Syk and Src Signaling during Borrelia burgdorferi Phagocytosis JO: Infect Immun http://www.kidney.de/pget.php?&tw=1&pmid=28717031 #FOAvip Phagocytosis of the Lyme disease-causing pathogen Borrelia burgdorferi has been shown to be important for generating an inflammatory response to the pathogen. As a result, understanding the mechanisms of phagocytosis has been an area of great interest in the field of Lyme disease. Several cell surface receptors that participate in B. burgdorferi phagocytosis have been reported, including the scavenger receptor MARCO and integrin ?3?1. We sought to define the mechanisms by which these receptors mediate phagocytosis and to identify signaling pathways activated downstream of these receptors upon contact with B. burgdorferi. We identified both Syk and Src signaling pathways as ones that participate in B. burgdorferi phagocytosis and the resulting cytokine activation. In our studies, we found that both MARCO and integrin ?1 play a role in the activation of the Src kinase pathway. However, only integrin ?1 participates in the activation of Syk. Interestingly, the integrin activates Syk without the help of the signaling adaptor Dap12 or FcR?. Thus, we report that multiple pathways participate in B. burgdorferi internalization and that different cell surface receptors act simultaneously in cooperation and independently to mediate phagocytosis. Twit Text FOAVip Phagocytic Receptors Activate Syk and Src Signaling during Borrelia burgdorferi Phagocytosis ????Infect Immun http://www.kidney.de/pget.php?&tw=1&pmid=28717031 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28717031 #FOAvip English Wikipedia <ref>{{Cite pmid|28717031}}</ref> Phagocytic Receptors Activate Syk and Src Signaling during Borrelia burgdorferi Phagocytosis #MMPMID28717031 Killpack TL; Ballesteros M; Bunnell SC; Bedugnis A; Kobzik L; Hu LT; Petnicki-Ocwieja T Infect Immun 2017[Oct]; 85 (10): ä PMID28717031show ga Phagocytosis of the Lyme disease-causing pathogen Borrelia burgdorferi has been shown to be important for generating an inflammatory response to the pathogen. As a result, understanding the mechanisms of phagocytosis has been an area of great interest in the field of Lyme disease. Several cell surface receptors that participate in B. burgdorferi phagocytosis have been reported, including the scavenger receptor MARCO and integrin ?3?1. We sought to define the mechanisms by which these receptors mediate phagocytosis and to identify signaling pathways activated downstream of these receptors upon contact with B. burgdorferi. We identified both Syk and Src signaling pathways as ones that participate in B. burgdorferi phagocytosis and the resulting cytokine activation. In our studies, we found that both MARCO and integrin ?1 play a role in the activation of the Src kinase pathway. However, only integrin ?1 participates in the activation of Syk. Interestingly, the integrin activates Syk without the help of the signaling adaptor Dap12 or FcR?. Thus, we report that multiple pathways participate in B. burgdorferi internalization and that different cell surface receptors act simultaneously in cooperation and independently to mediate phagocytosis. äPhagocytic Receptors Activate Syk and Src Signaling during Borrelia bu(epmc).pdf DeepDyve Pubget Overpricing