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10.1038/s41598-017-11912-8 http://scihub22266oqcxt.onion/10.1038/s41598-017-11912-8 C5607320!5607320 !28931892     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28931892 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 12000 Nephropedia Template TP {{tp|p=28931892 |t=2017. New views on phototransduction from atomic force microscopy and single molecule force spectroscopy on native rods |pdf=|usr=}}{{28931892 }} gab.com Text New views on phototransduction from atomic force microscopy and single molecule force spectroscopy on native rods JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28931892 #FOAvip By combining atomic force microscopy (AFM) imaging and single-molecule force spectroscopy (SMFS), we analyzed membrane proteins of the rod outer segments (OS). With this combined approach we were able to study the membrane proteins in their natural environment. In the plasma membrane we identified native cyclic nucleotide-gated (CNG) channels which are organized in single file strings. We also identified rhodopsin located both in the discs and in the plasma membrane. SMFS reveals strikingly different mechanical properties of rhodopsin unfolding in the two environments. Molecular dynamic simulations suggest that this difference is likely to be related to the higher hydrophobicity of the plasma membrane, due to the higher cholesterol concentration. This increases rhodopsin mechanical stability lowering the rate of transition towards its active form, hindering, in this manner, phototransduction. Twit Text FOAVip New views on phototransduction from atomic force microscopy and single molecule force spectroscopy on native rods ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28931892 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28931892 #FOAvip English Wikipedia <ref>{{Cite pmid|28931892 }}</ref> New views on phototransduction from atomic force microscopy and single molecule force spectroscopy on native rods #MMPMID28931892 Maity S ; Ilieva N ; Laio A ; Torre V ; Mazzolini M Sci Rep 2017[Sep]; 7 (1 ): 12000 PMID28931892 show ga By combining atomic force microscopy (AFM) imaging and single-molecule force spectroscopy (SMFS), we analyzed membrane proteins of the rod outer segments (OS). With this combined approach we were able to study the membrane proteins in their natural environment. In the plasma membrane we identified native cyclic nucleotide-gated (CNG) channels which are organized in single file strings. We also identified rhodopsin located both in the discs and in the plasma membrane. SMFS reveals strikingly different mechanical properties of rhodopsin unfolding in the two environments. Molecular dynamic simulations suggest that this difference is likely to be related to the higher hydrophobicity of the plasma membrane, due to the higher cholesterol concentration. This increases rhodopsin mechanical stability lowering the rate of transition towards its active form, hindering, in this manner, phototransduction. |Algorithms [MESH] |Animals [MESH] |Cell Membrane/metabolism/physiology [MESH] |Light Signal Transduction/*physiology [MESH] |Male [MESH] |Mechanical Phenomena [MESH] |Membrane Proteins/metabolism [MESH] |Microscopy, Atomic Force/*methods [MESH] |Molecular Dynamics Simulation [MESH] |Rhodopsin/metabolism [MESH] |Rod Cell Outer Segment/metabolism/*physiology [MESH] |Single Molecule Imaging/*methods [MESH] |Xenopus Proteins/metabolism [MESH]New views on phototransduction from atomic force microscopy and single(epmc).pdf DeepDyve Pubget Overpricing