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2017 ; 7
(1
): 11968
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English Wikipedia
Serum 1,5-anhydroglucitol when used with fasting plasma glucose improves the
efficiency of diabetes screening in a Chinese population
#MMPMID28931928
Ying L
; He X
; Ma X
; Shen Y
; Su H
; Peng J
; Wang Y
; Bao Y
; Zhou J
; Jia W
Sci Rep
2017[Sep]; 7
(1
): 11968
PMID28931928
show ga
Serum 1,5-anhydroglucitol (1,5-AG) levels can not only accurately reflect the
mean blood glucose over the previous 1-2 weeks in diabetic patients but also
offers the advantage of representing postprandial glucose. To evaluate the
clinical significance of 1,5-AG in diabetes detection, especially when used in
combination with fasting plasma glucose (FPG), a total of 3098 participants at
high risk for diabetes (1467 men, 1631 women) were enrolled. A total of 1471
(47.5%) participants were diagnosed with diabetes, and the mean 1,5-AG level in
the diabetic group was significantly lower than that in non-diabetic group [12.5
(7.8-17.5) ?g/mL vs. 20.5 (15.3-26.4) ?g/mL, P?0.001]. The optimal cut-off
point was 15.9 ?g/mL, for which the sensitivity, specificity, and area under the
curve (AUC) were 69.2%, 72.3%, and 0.781, respectively. For the combination of
FPG and 1,5-AG, the sensitivity, specificity, and AUC improved to 82.5%, 83.5%,
and 0.912, respectively. This method helped 75.8% of the participants avoid an
oral glucose tolerance test (OGTT), reducing the need to carry out the OGTT by
43.9% compared to the use of the FPG criterion only. In conclusion, the addition
of FPG to serum 1,5-AG improves the efficiency of diabetes screening in the
Chinese population.