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10.1038/s41467-017-00578-5 http://scihub22266oqcxt.onion/10.1038/s41467-017-00578-5 C5606997!5606997!28931820     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28931820|t=2017. The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma |pdf=|usr=}}{{28931820}} gab.com Text The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28931820 #FOAvip FAM46C is one of the most frequently mutated genes in multiple myeloma. Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene expression. Reintroduction of active FAM46C into multiple myeloma cell lines, but not its catalytically-inactive mutant, leads to broad polyadenylation and stabilization of mRNAs strongly enriched with those encoding endoplasmic reticulum-targeted proteins and induces cell death. Moreover, silencing of FAM46C in multiple myeloma cells expressing WT protein enhance cell proliferation. Finally, using a FAM46C-FLAG knock-in mouse strain, we show that the FAM46C protein is strongly induced during activation of primary splenocytes and that B lymphocytes isolated from newly generated FAM46C KO mice proliferate faster than those isolated from their WT littermates. Concluding, our data clearly indicate that FAM46C works as an onco-suppressor, with the specificity for B-lymphocyte lineage from which multiple myeloma originates. Twit Text FOAVip The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28931820 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28931820 #FOAvip English Wikipedia <ref>{{Cite pmid|28931820}}</ref> The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma #MMPMID28931820 Mroczek S; Chlebowska J; Kuli?ski TM; Gewartowska O; Gruchota J; Cysewski D; Liudkovska V; Borsuk E; Nowis D; Dziembowski A Nat Commun 2017[]; 8 (ä): ä PMID28931820show ga FAM46C is one of the most frequently mutated genes in multiple myeloma. Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene expression. Reintroduction of active FAM46C into multiple myeloma cell lines, but not its catalytically-inactive mutant, leads to broad polyadenylation and stabilization of mRNAs strongly enriched with those encoding endoplasmic reticulum-targeted proteins and induces cell death. Moreover, silencing of FAM46C in multiple myeloma cells expressing WT protein enhance cell proliferation. Finally, using a FAM46C-FLAG knock-in mouse strain, we show that the FAM46C protein is strongly induced during activation of primary splenocytes and that B lymphocytes isolated from newly generated FAM46C KO mice proliferate faster than those isolated from their WT littermates. Concluding, our data clearly indicate that FAM46C works as an onco-suppressor, with the specificity for B-lymphocyte lineage from which multiple myeloma originates. äThe non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor(epmc).pdf DeepDyve Pubget Overpricing