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2017 ; 18
(Suppl 10
): 395
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English Wikipedia
CellNetVis: a web tool for visualization of biological networks using
force-directed layout constrained by cellular components
#MMPMID28929969
Heberle H
; Carazzolle MF
; Telles GP
; Meirelles GV
; Minghim R
BMC Bioinformatics
2017[Sep]; 18
(Suppl 10
): 395
PMID28929969
show ga
BACKGROUND: The advent of "omics" science has brought new perspectives in
contemporary biology through the high-throughput analyses of molecular
interactions, providing new clues in protein/gene function and in the
organization of biological pathways. Biomolecular interaction networks, or
graphs, are simple abstract representations where the components of a cell (e.g.
proteins, metabolites etc.) are represented by nodes and their interactions are
represented by edges. An appropriate visualization of data is crucial for
understanding such networks, since pathways are related to functions that occur
in specific regions of the cell. The force-directed layout is an important and
widely used technique to draw networks according to their topologies. Placing the
networks into cellular compartments helps to quickly identify where network
elements are located and, more specifically, concentrated. Currently, only a few
tools provide the capability of visually organizing networks by cellular
compartments. Most of them cannot handle large and dense networks. Even for small
networks with hundreds of nodes the available tools are not able to reposition
the network while the user is interacting, limiting the visual exploration
capability. RESULTS: Here we propose CellNetVis, a web tool to easily display
biological networks in a cell diagram employing a constrained force-directed
layout algorithm. The tool is freely available and open-source. It was originally
designed for networks generated by the Integrated Interactome System and can be
used with networks from others databases, like InnateDB. CONCLUSIONS: CellNetVis
has demonstrated to be applicable for dynamic investigation of complex networks
over a consistent representation of a cell on the Web, with capabilities not
matched elsewhere.