Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26648190&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 FEBS+J 2016 ; 283 (14): 2577-98 Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Protease Signaling in Animal and Plant Regulated Cell Death #MMPMID26648190
Salvesen GS; Hempel A; Coll NS
FEBS J 2016[Jul]; 283 (14): 2577-98 PMID26648190show ga
The objective of this review is to highlight the proteases required for regulated cell death mechanisms in animals and plants. Our aim is to be incisive, and not inclusive of all the animal proteases that have been implicated in various publications. We aim to focus on instances when several publications from disparate groups have demonstrated the involvement of an animal protease, and also when there is substantial biochemical, mechanistic and genetic evidence. In doing so we can cull the literature to a handful of proteases, covering most of the known regulated cell death mechanisms ? apoptosis, regulated necrosis, necroptosis, pyroptosis, and NETosis in animals. In plants the literature is younger and not as extensive as for mammals, but the molecular drivers of vacuolar death, necrosis, and the hypersensitive response in plants are becoming clearer. Each of these death mechanisms has at least one proteolytic component that plays a major role in controlling the pathway, and sometimes they combine in networks to regulate cell death/survival decision nodes. Some similarities are found among animal and plant cell death proteases, but overall the pathways that they govern are kingdom-specific with very little overlap.