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10.1016/j.molmet.2017.06.019 http://scihub22266oqcxt.onion/10.1016/j.molmet.2017.06.019 C5605733!5605733 !28951820     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28951820 &cmd=llinks): Failed to open stream: HTTP request failed! 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Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis |pdf=|usr=}}{{28951820 }} gab.com Text Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis JO: Mol Metab http://www.kidney.de/pget.php?&tw=1&pmid=28951820 #FOAvip BACKGROUND: Plasma insulin levels are predominantly the product of the morphological mass of insulin producing beta cells in the pancreatic islets of Langerhans and the functional status of each of these beta cells. Thus, deficiency in either beta cell mass or function, or both, can lead to insufficient levels of insulin, resulting in hyperglycemia and diabetes. Nonetheless, the precise contribution of beta cell mass and function to the pathogenesis of diabetes as well as the underlying mechanisms are still unclear. In the past, this was largely due to the restricted number of technologies suitable for studying the scarcely accessible human beta cells. However, in recent years, a number of new platforms have been established to expand the available techniques and to facilitate deeper insight into the role of human beta cell mass and function as cause for diabetes and as potential treatment targets. SCOPE OF REVIEW: This review discusses the current knowledge about contribution of human beta cell mass and function to different stages of type 1 and type 2 diabetes pathogenesis. Furthermore, it highlights standard and newly developed technological platforms for the study of human beta cell biology, which can be used to increase our understanding of beta cell mass and function in human glucose homeostasis. MAJOR CONCLUSIONS: In contrast to early disease models, recent studies suggest that in type 1 and type 2 diabetes impairment of beta cell function is an early feature of disease pathogenesis while a substantial decrease in beta cell mass occurs more closely to clinical manifestation. This suggests that, in addition to beta cell mass replacement for late stage therapies, the development of novel strategies for protection and recovery of beta cell function could be most promising for successful diabetes treatment and prevention. The use of today's developing and wide range of technologies and platforms for the study of human beta cells will allow for a more detailed investigation of the underlying mechanisms and will facilitate development of treatment approaches to specifically target human beta cell mass and function. Twit Text FOAVip Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis ????Mol Metab http://www.kidney.de/pget.php?&tw=1&pmid=28951820 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28951820 #FOAvip English Wikipedia <ref>{{Cite pmid|28951820 }}</ref> Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis #MMPMID28951820 Chen C ; Cohrs CM ; Stertmann J ; Bozsak R ; Speier S Mol Metab 2017[Sep]; 6 (9 ): 943-957 PMID28951820 show ga BACKGROUND: Plasma insulin levels are predominantly the product of the morphological mass of insulin producing beta cells in the pancreatic islets of Langerhans and the functional status of each of these beta cells. Thus, deficiency in either beta cell mass or function, or both, can lead to insufficient levels of insulin, resulting in hyperglycemia and diabetes. Nonetheless, the precise contribution of beta cell mass and function to the pathogenesis of diabetes as well as the underlying mechanisms are still unclear. In the past, this was largely due to the restricted number of technologies suitable for studying the scarcely accessible human beta cells. However, in recent years, a number of new platforms have been established to expand the available techniques and to facilitate deeper insight into the role of human beta cell mass and function as cause for diabetes and as potential treatment targets. SCOPE OF REVIEW: This review discusses the current knowledge about contribution of human beta cell mass and function to different stages of type 1 and type 2 diabetes pathogenesis. Furthermore, it highlights standard and newly developed technological platforms for the study of human beta cell biology, which can be used to increase our understanding of beta cell mass and function in human glucose homeostasis. MAJOR CONCLUSIONS: In contrast to early disease models, recent studies suggest that in type 1 and type 2 diabetes impairment of beta cell function is an early feature of disease pathogenesis while a substantial decrease in beta cell mass occurs more closely to clinical manifestation. This suggests that, in addition to beta cell mass replacement for late stage therapies, the development of novel strategies for protection and recovery of beta cell function could be most promising for successful diabetes treatment and prevention. The use of today's developing and wide range of technologies and platforms for the study of human beta cells will allow for a more detailed investigation of the underlying mechanisms and will facilitate development of treatment approaches to specifically target human beta cell mass and function. |Animals [MESH] |Diabetes Mellitus, Type 1/metabolism [MESH] |Diabetes Mellitus, Type 2/metabolism [MESH] |Diabetes Mellitus/drug therapy/*physiopathology [MESH] |Disease Models, Animal [MESH] |Humans [MESH] |Hyperglycemia/metabolism [MESH] |Insulin-Secreting Cells/*metabolism/*physiology [MESH] |Insulin/metabolism [MESH] |Islets of Langerhans Transplantation [MESH]Human beta cell mass and function in diabetes: Recent advances in know(epmc).pdf DeepDyve Pubget Overpricing