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10.1016/j.molmet.2017.04.010 http://scihub22266oqcxt.onion/10.1016/j.molmet.2017.04.010 C5605729!5605729!28951821     free     free     free       Mol+Metab 2017 ; 6 (9): 958-73 Nephropedia Template TP {{tp|p=28951821|t=2017. The dynamic plasticity of insulin production in ?-cells |pdf=|usr=}}{{28951821}} gab.com Text The dynamic plasticity of insulin production in -cells JO: Mol Metab http://www.kidney.de/pget.php?&tw=1&pmid=28951821 #FOAvip Background: Although the insulin-producing pancreatic ?-cells are quite capable of adapting to both acute and chronic changes in metabolic demand, persistently high demand for insulin will ultimately lead to their progressive dysfunction and eventual loss. Recent and historical studies highlight the importance of ?resting? the ?-cell as a means of preserving functional ?-cell mass. Scope of Review: We provide experimental evidence to highlight the remarkable plasticity for insulin production and secretion by the pancreatic ?-cell alongside some clinical evidence that supports leveraging this unique ability to preserve ?-cell function. Major conclusions: Treatment strategies for type 2 diabetes mellitus (T2DM) targeted towards reducing the systemic metabolic burden, rather than demanding greater insulin production from an already beleaguered ?-cell, should be emphasized to maintain endogenous insulin secretory function and delay the progression of T2DM. Twit Text FOAVip The dynamic plasticity of insulin production in -cells ????Mol Metab http://www.kidney.de/pget.php?&tw=1&pmid=28951821 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28951821 #FOAvip English Wikipedia <ref>{{Cite pmid|28951821}}</ref> The dynamic plasticity of insulin production in ?-cells #MMPMID28951821 Boland BB; Rhodes CJ; Grimsby JS Mol Metab 2017[Sep]; 6 (9): 958-73 PMID28951821show ga Background: Although the insulin-producing pancreatic ?-cells are quite capable of adapting to both acute and chronic changes in metabolic demand, persistently high demand for insulin will ultimately lead to their progressive dysfunction and eventual loss. Recent and historical studies highlight the importance of ?resting? the ?-cell as a means of preserving functional ?-cell mass. Scope of Review: We provide experimental evidence to highlight the remarkable plasticity for insulin production and secretion by the pancreatic ?-cell alongside some clinical evidence that supports leveraging this unique ability to preserve ?-cell function. Major conclusions: Treatment strategies for type 2 diabetes mellitus (T2DM) targeted towards reducing the systemic metabolic burden, rather than demanding greater insulin production from an already beleaguered ?-cell, should be emphasized to maintain endogenous insulin secretory function and delay the progression of T2DM. äThe dynamic plasticity of insulin production in ?-cells (epmc).pdf DeepDyve Pubget Overpricing