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10.1038/s41467-017-00551-2 http://scihub22266oqcxt.onion/10.1038/s41467-017-00551-2 C5605640!5605640!28928465     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28928465|t=2017. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis |pdf=|usr=}}{{28928465}} gab.com Text Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28928465 #FOAvip Adenosine/adenosine receptor-mediated signaling has been implicated in the development of various ischemic diseases, including ischemic retinopathies. Here, we show that the adenosine A2a receptor (ADORA2A) promotes hypoxia-inducible transcription factor-1 (HIF-1)-dependent endothelial cell glycolysis, which is crucial for pathological angiogenesis in proliferative retinopathies. Adora2a expression is markedly increased in the retina of mice with oxygen-induced retinopathy (OIR). Endothelial cell-specific, but not macrophage-specific Adora2a deletion decreases key glycolytic enzymes and reduces pathological neovascularization in the OIR mice. In human primary retinal microvascular endothelial cells, hypoxia induces the expression of ADORA2A by activating HIF-2?. ADORA2A knockdown decreases hypoxia-induced glycolytic enzyme expression, glycolytic flux, and endothelial cell proliferation, sprouting and tubule formation. Mechanistically, ADORA2A activation promotes the transcriptional induction of glycolytic enzymes via ERK- and Akt-dependent translational activation of HIF-1? protein. Taken together, these findings advance translation of ADORA2A as a therapeutic target in the treatment of proliferative retinopathies and other diseases dependent on pathological angiogenesis. Twit Text FOAVip Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28928465 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28928465 #FOAvip English Wikipedia <ref>{{Cite pmid|28928465}}</ref> Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis #MMPMID28928465 Liu Z; Yan S; Wang J; Xu Y; Wang Y; Zhang S; Xu X; Yang Q; Zeng X; Zhou Y; Gu X; Lu S; Fu Z; Fulton DJ; Weintraub NL; Caldwell RB; Zhang W; Wu C; Liu XL; Chen JF; Ahmad A; Kaddour-Djebbar I; Al-Shabrawey M; Li Q; Jiang X; Sun Y; Sodhi A; Smith L; Hong M; Huo Y Nat Commun 2017[]; 8 (ä): ä PMID28928465show ga Adenosine/adenosine receptor-mediated signaling has been implicated in the development of various ischemic diseases, including ischemic retinopathies. Here, we show that the adenosine A2a receptor (ADORA2A) promotes hypoxia-inducible transcription factor-1 (HIF-1)-dependent endothelial cell glycolysis, which is crucial for pathological angiogenesis in proliferative retinopathies. Adora2a expression is markedly increased in the retina of mice with oxygen-induced retinopathy (OIR). Endothelial cell-specific, but not macrophage-specific Adora2a deletion decreases key glycolytic enzymes and reduces pathological neovascularization in the OIR mice. In human primary retinal microvascular endothelial cells, hypoxia induces the expression of ADORA2A by activating HIF-2?. ADORA2A knockdown decreases hypoxia-induced glycolytic enzyme expression, glycolytic flux, and endothelial cell proliferation, sprouting and tubule formation. Mechanistically, ADORA2A activation promotes the transcriptional induction of glycolytic enzymes via ERK- and Akt-dependent translational activation of HIF-1? protein. Taken together, these findings advance translation of ADORA2A as a therapeutic target in the treatment of proliferative retinopathies and other diseases dependent on pathological angiogenesis. äEndothelial adenosine A2a receptor-mediated glycolysis is essential fo(epmc).pdf DeepDyve Pubget Overpricing