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10.1371/journal.pone.0184888 http://scihub22266oqcxt.onion/10.1371/journal.pone.0184888 C5605005!5605005 !28926607     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28926607 &cmd=llinks): Failed to open stream: HTTP request failed! 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The novel mineralocorticoid receptor antagonist finerenone attenuates neointima formation after vascular injury |pdf=|usr=}}{{28926607 }} gab.com Text The novel mineralocorticoid receptor antagonist finerenone attenuates neointima formation after vascular injury JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28926607 #FOAvip BACKGROUND: The novel nonsteroidal mineralocorticoid receptor (MR) antagonist finerenone holds promise to be safe and efficient in the treatment of patients with heart failure and/or chronic kidney disease. However, its effects on vascular function remain elusive. PURPOSE: The aim of this study was to determine the functional effect of selective MR antagonism by finerenone in vascular cells in vitro and the effect on vascular remodeling following acute vascular injury in vivo. METHODS AND RESULTS: In vitro, finerenone dose-dependently reduced aldosterone-induced smooth muscle cell (SMC) proliferation, as quantified by BrdU incorporation, and prevented aldosterone-induced endothelial cell (EC) apoptosis, as measured with a flow cytometry based caspase 3/7 activity assay. In vivo, oral application of finerenone resulted in an accelerated re-endothelialization 3 days following electric injury of the murine carotid artery. Furthermore, finerenone treatment inhibited intimal and medial cell proliferation following wire-induced injury of the murine femoral artery 10 days following injury and attenuated neointimal lesion formation 21 days following injury. CONCLUSION: Finerenone significantly reduces apoptosis of ECs and simultaneously attenuates SMC proliferation, resulting in accelerated endothelial healing and reduced neointima formation of the injured vessels. Thus, finerenone appears to provide favorable vascular effects through restoring vascular integrity and preventing adverse vascular remodeling. Twit Text FOAVip The novel mineralocorticoid receptor antagonist finerenone attenuates neointima formation after vascular injury ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28926607 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28926607 #FOAvip English Wikipedia <ref>{{Cite pmid|28926607 }}</ref> The novel mineralocorticoid receptor antagonist finerenone attenuates neointima formation after vascular injury #MMPMID28926607 Dutzmann J ; Musmann RJ ; Haertlé M ; Daniel JM ; Sonnenschein K ; Schäfer A ; Kolkhof P ; Bauersachs J ; Sedding DG PLoS One 2017[]; 12 (9 ): e0184888 PMID28926607 show ga BACKGROUND: The novel nonsteroidal mineralocorticoid receptor (MR) antagonist finerenone holds promise to be safe and efficient in the treatment of patients with heart failure and/or chronic kidney disease. However, its effects on vascular function remain elusive. PURPOSE: The aim of this study was to determine the functional effect of selective MR antagonism by finerenone in vascular cells in vitro and the effect on vascular remodeling following acute vascular injury in vivo. METHODS AND RESULTS: In vitro, finerenone dose-dependently reduced aldosterone-induced smooth muscle cell (SMC) proliferation, as quantified by BrdU incorporation, and prevented aldosterone-induced endothelial cell (EC) apoptosis, as measured with a flow cytometry based caspase 3/7 activity assay. In vivo, oral application of finerenone resulted in an accelerated re-endothelialization 3 days following electric injury of the murine carotid artery. Furthermore, finerenone treatment inhibited intimal and medial cell proliferation following wire-induced injury of the murine femoral artery 10 days following injury and attenuated neointimal lesion formation 21 days following injury. CONCLUSION: Finerenone significantly reduces apoptosis of ECs and simultaneously attenuates SMC proliferation, resulting in accelerated endothelial healing and reduced neointima formation of the injured vessels. Thus, finerenone appears to provide favorable vascular effects through restoring vascular integrity and preventing adverse vascular remodeling. |Aldosterone/toxicity [MESH] |Animals [MESH] |Apoptosis/drug effects [MESH] |Carotid Arteries/pathology [MESH] |Carotid Artery Injuries/*drug therapy/etiology/pathology [MESH] |Cell Line [MESH] |Cell Proliferation/drug effects [MESH] |Disease Models, Animal [MESH] |Human Umbilical Vein Endothelial Cells [MESH] |Humans [MESH] |Leukocytes/cytology/immunology/metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mineralocorticoid Receptor Antagonists/pharmacology/*therapeutic use [MESH] |Muscle, Smooth, Vascular/cytology/metabolism [MESH] |Naphthyridines/pharmacology/*therapeutic use [MESH] |Neointima/pathology/prevention & control [MESH]The novel mineralocorticoid receptor antagonist finerenone attenuates (epmc).pdf DeepDyve Pubget Overpricing