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10.4236/oji.2017.71001

http://scihub22266oqcxt.onion/10.4236/oji.2017.71001
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C5604888!5604888!28944101
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suck abstract from ncbi


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pmid28944101      Open+J+Immunol 2017 ; 7 (1): 1-17
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  • Soluble MICB in Plasma and Urine Explains Population Expansions of NKG2D+CD4 T Cells Inpatients with Juvenile-Onset Systemic Lupus Erythematosus #MMPMID28944101
  • Hamada S; Caballero-Benitez A; Duran KL; Stevens AM; Spies T; Groh V
  • Open J Immunol 2017[Mar]; 7 (1): 1-17 PMID28944101show ga
  • Abnormal NKG2D ligand expression has been implicated in the initiation and maintenance of various auto-inflammatory disorders including systemic lupus erythematosus (SLE). This study?s goal was to identify the cellular contexts providing NKG2D ligands for stimulation of the immunosuppressive NKG2D+CD4 T cell subset that has been implicated in modulating juvenile-onset SLE disease activity. Although previous observations with NKG2D+CD4 T cells in healthy individuals pointed towards peripheral B cell and myeloid cell compartments as possible sites of enhanced NKG2DL presence, we found no evidence for a disease-associated increase of NKG2DL-positivity among juvenile-onset SLE B cells and monocytes. However, juvenile-onset SLE patient plasma and matched urine samples were positive by ELISA for the soluble form of the NKG2D ligands MICA and MICB, suggesting that kidney and/or peripheral blood may constitute the NKG2DL positive microenvironments driving NKG2D+CD4 T cell population expansions in this disease.
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