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2017 ; 3
(1
): e000449
Nephropedia Template TP
gab.com Text
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English Wikipedia
Validation of the EULAR/ERA-EDTA recommendations for the management of
ANCA-associated vasculitis by disease content experts
#MMPMID28955487
Yates M
; Watts R
; Bajema I
; Cid M
; Crestani B
; Hauser T
; Hellmich B
; Holle J
; Laudien M
; Little MA
; Luqmani RA
; Mahr A
; Merkel P
; Mills J
; Mooney J
; Segelmark M
; Tesar V
; Westman KWA
; Vaglio A
; Yalç?nda? N
; Jayne DR
; Mukhtyar C
RMD Open
2017[]; 3
(1
): e000449
PMID28955487
show ga
The European League Against Rheumatism recommendations for the management of
antineutrophil cytoplasmic antibody-associated vasculitis have been recently
published. Unique to recommendation development, they were also voted on by
members of a learned society. This paper explores the wider validity of the
recommendations among people who self-identify as clinicians caring for patients
with vasculitis. In addition to the task force, a learned society (European
Vasculitis Society-EUVAS) was invited, through online survey, to rate
independently the strength of evidence of each recommendation to obtain an
indication of the agreement among the final target audience and ultimate
end-users of the recommendations. The survey took place in June 2015. Of the 158
EUVAS members surveyed, there were 88 responses (55.7%). There was a large degree
of agreement in the voting patterns between EUVAS survey participants and task
force members. Notable exceptions were lower grades for the recommendation of the
use of rituximab for remission induction in patients with eosinophilic
granulomatosis with polyangiitis and for methotrexate and mycophenolate mofetil
as remission maintenance agents in patients with granulomatosis with
polyangiitis/microscopic polyangiitis by EUVAS members. These results are
encouraging and suggest that the voting patterns of the task force are
representative of the wider vasculitis community. We recommend future
recommendations adopt this approach for data/expert-based treatment guidelines,
especially for multisystem diseases.
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