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2017 ; 8
(15
): 3099-3104
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English Wikipedia
Systematic Correlation Analyses of Circulating Tumor Cells with Clinical
Variables and Tumor Markers in Lung Cancer Patients
#MMPMID28928901
Wang X
; Ma K
; Yang Z
; Cui J
; He H
; Hoffman AR
; Hu JF
; Li W
J Cancer
2017[]; 8
(15
): 3099-3104
PMID28928901
show ga
Measurement of circulating tumor cells (CTC) offers promise as a clinical
biomarker to monitor disease status, therapeutic response, and progression in
cancer patients. However, its clinical value in lung cancer patients has not been
fully explored. We systematically evaluate the association of CTCs with clinical
variables and tumor markers in a cohort of lung cancer patients. Using the
CELLSEARCH System, CTCs were detected in both small cell lung cancer (SCLC) and
non-small cell lung cancer (NSCLC) patients prior to therapy. Univariate analysis
revealed that detection of CTC was related to histology, stage, tumor size,
invasiveness, and lymphatic metastasis. CTCs were associated with distant
metastases in NSCLC, but not in SCLC. Using multivariate analysis, we found that
CTCs were independently correlated with disease stage, SCLC, and elevated serum
neuron-specific enolase (NSE). These data suggest that CTCs are more likely to be
detected in patients with stage IV disease and with SCLC, and that elevated serum
NSE predicts the presence of CTCs.