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2017 ; 14
(ä): 21
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Evaluation of a competitive hepcidin ELISA assay in the differential diagnosis of
iron deficiency anaemia with concurrent inflammation and anaemia of inflammation
in elderly patients
#MMPMID28936123
Karlsson T
J Inflamm (Lond)
2017[]; 14
(ä): 21
PMID28936123
show ga
In this study, a competitive hepcidin ELISA assay was evaluated for its ability
to differentiate between iron deficiency anaemia with concurrent inflammation and
anaemia of inflammation in elderly patients, using the absence of stainable bone
marrow iron as the diagnostic criterion for iron deficiency. In addition,
correlation coefficients for hepcidin versus C-reactive protein, ferritin and
interleukin-6 were determined. The optimal cut-off for hepcidin was 21 ?g/L,
corresponding to sensitivity and specificity of 100% and 67%, respectively, for
iron deficiency. For ferritin, a sensitivity and specificity of 91% and 83%,
respectively, correspond to an optimal cut-off of 87 ?g/L. Receiver operating
characteristics curve analysis revealed that ELISA analysis of hepcidin is not
superior to ferritin in the diagnosis of iron deficiency in elderly anaemic
patients with concurrent inflammation. Hepcidin shows a strong positive
correlation with ferritin, and also correlates positively with C-reactive protein
in this patient population.