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10.1016/j.urolonc.2016.05.027 http://scihub22266oqcxt.onion/10.1016/j.urolonc.2016.05.027 C5604255!5604255 !27692835     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27692835 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Urol+Oncol 2016 ; 34 (11 ): 483.e1-483.e8 Nephropedia Template TP {{tp|p=27692835 |t=2016. Hepatoma-derived growth factor: A survival-related protein in prostate oncogenesis and a potential target for vitamin K2 |pdf=|usr=}}{{27692835 }} gab.com Text Hepatoma-derived growth factor: A survival-related protein in prostate oncogenesis and a potential target for vitamin K2 JO: Urol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27692835 #FOAvip Hepatoma-derived growth factor (HDGF) is a heparin-binding growth factor, which has previously been shown to be expressed in a variety of cancers. HDGF overexpression has also previously been correlated with a poor prognosis in several cancers. The significance of HDGF in prostate cancer, however, has not been investigated. Here, we show that HDGF is overexpressed in both androgen-sensitive LNCaP cells and androgen-insensitive DU145, 22RV1, and PC-3 cells. Forced overexpression enhanced cell viability of RWPE-1 cells, whereas HDGF knockdown reduced cell proliferation in human prostate cancer cells. We also show that HDGF may serve as a survival-related protein as ectopic overexpression of HDGF in RWPE cells up-regulated the expression of antiapoptosis proteins cyclin E and BCL-2, whereas simultaneously down-regulating proapoptotic protein BAX. Western blot analysis also showed that HDGF overexpression modulated the activity of phospho-AKT as well as NF-kB, and these results correlated with in vitro migration and invasion assays. We next assessed the therapeutic potential of HDGF inhibition with a HDGF monoclonal antibody and vitamin k(2), showing reduced cell proliferation as well as inhibition of NF-kB expression in HDGF overexpressed RWPE cells treated with a HDGF monoclonal antibody and vitamin K(2). Collectively, our results suggest that HDGF is a relevant protein in prostate oncogenesis and may serve as a potential therapeutic target in prostate cancer. Twit Text FOAVip Hepatoma-derived growth factor: A survival-related protein in prostate oncogenesis and a potential target for vitamin K2 ????Urol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27692835 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27692835 #FOAvip English Wikipedia <ref>{{Cite pmid|27692835 }}</ref> Hepatoma-derived growth factor: A survival-related protein in prostate oncogenesis and a potential target for vitamin K2 #MMPMID27692835 Shetty A ; Dasari S ; Banerjee S ; Gheewala T ; Zheng G ; Chen A ; Kajdacsy-Balla A ; Bosland MC ; Munirathinam G Urol Oncol 2016[Nov]; 34 (11 ): 483.e1-483.e8 PMID27692835 show ga Hepatoma-derived growth factor (HDGF) is a heparin-binding growth factor, which has previously been shown to be expressed in a variety of cancers. HDGF overexpression has also previously been correlated with a poor prognosis in several cancers. The significance of HDGF in prostate cancer, however, has not been investigated. Here, we show that HDGF is overexpressed in both androgen-sensitive LNCaP cells and androgen-insensitive DU145, 22RV1, and PC-3 cells. Forced overexpression enhanced cell viability of RWPE-1 cells, whereas HDGF knockdown reduced cell proliferation in human prostate cancer cells. We also show that HDGF may serve as a survival-related protein as ectopic overexpression of HDGF in RWPE cells up-regulated the expression of antiapoptosis proteins cyclin E and BCL-2, whereas simultaneously down-regulating proapoptotic protein BAX. Western blot analysis also showed that HDGF overexpression modulated the activity of phospho-AKT as well as NF-kB, and these results correlated with in vitro migration and invasion assays. We next assessed the therapeutic potential of HDGF inhibition with a HDGF monoclonal antibody and vitamin k(2), showing reduced cell proliferation as well as inhibition of NF-kB expression in HDGF overexpressed RWPE cells treated with a HDGF monoclonal antibody and vitamin K(2). Collectively, our results suggest that HDGF is a relevant protein in prostate oncogenesis and may serve as a potential therapeutic target in prostate cancer. |Adenocarcinoma/metabolism/*pathology [MESH] |Androgens [MESH] |Antibodies, Monoclonal/pharmacology [MESH] |Apoptosis/drug effects [MESH] |Cell Division/drug effects [MESH] |Cell Line, Tumor [MESH] |Cell Survival [MESH] |Cell Transformation, Neoplastic [MESH] |Drug Screening Assays, Antitumor [MESH] |Epithelial Cells/drug effects/metabolism [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Intercellular Signaling Peptides and Proteins/pharmacology/*physiology [MESH] |Male [MESH] |Molecular Targeted Therapy [MESH] |NF-kappa B/metabolism [MESH] |Neoplasm Proteins/biosynthesis/genetics [MESH] |Neoplasms, Hormone-Dependent/metabolism/pathology [MESH] |Prostate/cytology [MESH] |Prostatic Neoplasms, Castration-Resistant/metabolism/pathology [MESH] |Prostatic Neoplasms/metabolism/*pathology [MESH] |RNA Interference [MESH] |RNA, Small Interfering/pharmacology [MESH] |Recombinant Proteins/metabolism [MESH]Hepatoma-derived growth factor: A survival-related protein in prostate(epmc).pdf DeepDyve Pubget Overpricing