Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28923001
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 BMC+Genomics
2017 ; 18
(1
): 739
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
A molecular view of the normal human thyroid structure and function reconstructed
from its reference transcriptome map
#MMPMID28923001
Vitale L
; Piovesan A
; Antonaros F
; Strippoli P
; Pelleri MC
; Caracausi M
BMC Genomics
2017[Sep]; 18
(1
): 739
PMID28923001
show ga
BACKGROUND: The thyroid is the earliest endocrine structure to appear during
human development, and thyroid hormones are necessary for proper organism
development, in particular for the nervous system and heart, normal growth and
skeletal maturation. To date a quantitative, validated transcriptional atlas of
the whole normal human thyroid does not exist and the availability of a detailed
expression map might be an excellent occasion to investigate the many features of
the thyroid transcriptome. RESULTS: We present a view at the molecular level of
the normal human thyroid histology and physiology obtained by a systematic
meta-analysis of all the available gene expression profiles for the whole organ.
A quantitative transcriptome reference map was generated by using the TRAM
(Transcriptome Mapper) software able to combine, normalize and integrate a total
of 35 suitable datasets from different sources thus providing a typical reference
expression value for each of the 27,275 known, mapped transcripts obtained. The
experimental in vitro validation of data was performed by "Real-Time" reverse
transcription polymerase chain reaction showing an excellent correlation
coefficient (r = 0.93) with data obtained in silico. CONCLUSIONS: Our study
provides a quantitative global reference portrait of gene expression in the
normal human thyroid and highlights differential expression between normal human
thyroid and a pool of non-thyroid tissues useful for modeling correlations
between thyroidal gene expression and specific thyroid functions and diseases.
The experimental in vitro validation supports the possible usefulness of the
human thyroid transcriptome map as a reference for molecular studies of the
physiology and pathology of this organ.
free
free
free
