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10.1073/pnas.1710366114 http://scihub22266oqcxt.onion/10.1073/pnas.1710366114 C5604037!5604037!28847964     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (37): E7697-706 Nephropedia Template TP {{tp|p=28847964|t=2017. Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC |pdf=|usr=}}{{28847964}} gab.com Text Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28847964 #FOAvip Metabolic reprogramming is one of the hallmarks of cancer. However, the underlying mechanisms that regulate cancer metabolism are poorly understood. Here we performed multiomics-based analysis of paired normal?tumor tissues from patients with colorectal cancer, which revealed that the protooncogene protein MYC regulated global metabolic reprogramming of colorectal cancer by modulating 215 metabolic reactions. Importantly, this metabolic reprogramming occurred in a manner not associated with specific gene mutations in colorectal carcinogenesis. For many years, small-molecule or biologic inhibitors of MYC have been required. Here we demonstrate that knockdown of MYC downstream pyrimidine synthesis genes contributes to the suppression of colorectal cancer cell proliferation similar to MYC, and thus pyrimidine synthesis pathways could be potential targets for colorectal cancer therapy. Twit Text FOAVip Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28847964 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28847964 #FOAvip English Wikipedia <ref>{{Cite pmid|28847964}}</ref> Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC #MMPMID28847964 Satoh K; Yachida S; Sugimoto M; Oshima M; Nakagawa T; Akamoto S; Tabata S; Saitoh K; Kato K; Sato S; Igarashi K; Aizawa Y; Kajino-Sakamoto R; Kojima Y; Fujishita T; Enomoto A; Hirayama A; Ishikawa T; Taketo MM; Kushida Y; Haba R; Okano K; Tomita M; Suzuki Y; Fukuda S; Aoki M; Soga T Proc Natl Acad Sci U S A 2017[Sep]; 114 (37): E7697-706 PMID28847964show ga Metabolic reprogramming is one of the hallmarks of cancer. However, the underlying mechanisms that regulate cancer metabolism are poorly understood. Here we performed multiomics-based analysis of paired normal?tumor tissues from patients with colorectal cancer, which revealed that the protooncogene protein MYC regulated global metabolic reprogramming of colorectal cancer by modulating 215 metabolic reactions. Importantly, this metabolic reprogramming occurred in a manner not associated with specific gene mutations in colorectal carcinogenesis. For many years, small-molecule or biologic inhibitors of MYC have been required. Here we demonstrate that knockdown of MYC downstream pyrimidine synthesis genes contributes to the suppression of colorectal cancer cell proliferation similar to MYC, and thus pyrimidine synthesis pathways could be potential targets for colorectal cancer therapy. äGlobal metabolic reprogramming of colorectal cancer occurs at adenoma (epmc).pdf DeepDyve Pubget Overpricing