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10.1073/pnas.1706942114 http://scihub22266oqcxt.onion/10.1073/pnas.1706942114 C5604020!5604020!28847942     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (37): 9894-9 Nephropedia Template TP {{tp|p=28847942|t=2017. Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow |pdf=|usr=}}{{28847942}} gab.com Text Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28847942 #FOAvip Transport of nutrients and clearance of waste products are prerequisites for healthy brain function. It is still debated whether solutes are transported through the interstitial space by pressure-mediated bulk flow or by diffusion. Here we have simulated interstitial bulk flow within 3D electron microscope reconstructions of hippocampal tissue. We show that the permeability is one to two orders of magnitude lower than values typically seen in the literature, arguing against bulk flow as the dominant transport mechanism. Further, we show that solutes of all sizes are more easily transported through the interstitium by diffusion than by bulk flow. We conclude that clearance of waste products from the brain is largely based on diffusion of solutes through the interstitial space. Twit Text FOAVip Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28847942 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28847942 #FOAvip English Wikipedia <ref>{{Cite pmid|28847942}}</ref> Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow #MMPMID28847942 Holter KE; Kehlet B; Devor A; Sejnowski TJ; Dale AM; Omholt SW; Ottersen OP; Nagelhus EA; Mardal KA; Pettersen KH Proc Natl Acad Sci U S A 2017[Sep]; 114 (37): 9894-9 PMID28847942show ga Transport of nutrients and clearance of waste products are prerequisites for healthy brain function. It is still debated whether solutes are transported through the interstitial space by pressure-mediated bulk flow or by diffusion. Here we have simulated interstitial bulk flow within 3D electron microscope reconstructions of hippocampal tissue. We show that the permeability is one to two orders of magnitude lower than values typically seen in the literature, arguing against bulk flow as the dominant transport mechanism. Further, we show that solutes of all sizes are more easily transported through the interstitium by diffusion than by bulk flow. We conclude that clearance of waste products from the brain is largely based on diffusion of solutes through the interstitial space. äInterstitial solute transport in 3D reconstructed neuropil occurs by d(epmc).pdf DeepDyve Pubget Overpricing