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10.1073/pnas.1702946114 http://scihub22266oqcxt.onion/10.1073/pnas.1702946114 C5604003!5604003!28847925     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (37): E7766-75 Nephropedia Template TP {{tp|p=28847925|t=2017. NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy |pdf=|usr=}}{{28847925}} gab.com Text NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28847925 #FOAvip This study identifies a mutation in the NLRP3 gene that causes sensorineural hearing loss in human patients. NLRP3 encodes a protein important for innate immunity, secretion of the potent cytokine IL-1?, and inflammation. The hearing loss in three affected members of one family improved or completely resolved after treatment with IL-1? blockade therapy. This study shows that the mouse Nlrp3 gene is expressed in immune macrophage-like cells throughout the inner ear, which can be activated to release the potent cytokine IL-1?. These observations suggest that mutations of NLRP3 may cause hearing loss by local autoinflammation within the inner ear. This mechanism could underlie a variety of hearing-loss disorders of unknown etiology that might respond to IL-1? blockade therapy. Twit Text FOAVip NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28847925 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28847925 #FOAvip English Wikipedia <ref>{{Cite pmid|28847925}}</ref> NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy #MMPMID28847925 Nakanishi H; Kawashima Y; Kurima K; Chae JJ; Ross AM; Pinto-Patarroyo G; Patel SK; Muskett JA; Ratay JS; Chattaraj P; Park YH; Grevich S; Brewer CC; Hoa M; Kim HJ; Butman JA; Broderick L; Hoffman HM; Aksentijevich I; Kastner DL; Goldbach-Mansky R; Griffith AJ Proc Natl Acad Sci U S A 2017[Sep]; 114 (37): E7766-75 PMID28847925show ga This study identifies a mutation in the NLRP3 gene that causes sensorineural hearing loss in human patients. NLRP3 encodes a protein important for innate immunity, secretion of the potent cytokine IL-1?, and inflammation. The hearing loss in three affected members of one family improved or completely resolved after treatment with IL-1? blockade therapy. This study shows that the mouse Nlrp3 gene is expressed in immune macrophage-like cells throughout the inner ear, which can be activated to release the potent cytokine IL-1?. These observations suggest that mutations of NLRP3 may cause hearing loss by local autoinflammation within the inner ear. This mechanism could underlie a variety of hearing-loss disorders of unknown etiology that might respond to IL-1? blockade therapy. äNLRP3 mutation and cochlear autoinflammation cause syndromic and nonsy(epmc).pdf DeepDyve Pubget Overpricing