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10.1073/pnas.1621490114

http://scihub22266oqcxt.onion/10.1073/pnas.1621490114
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C5603994!5603994!28847966
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suck abstract from ncbi


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pmid28847966      Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (37): 9942-7
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  • The molecular dynamics of long noncoding RNA control of transcription in PTEN and its pseudogene #MMPMID28847966
  • Lister N; Shevchenko G; Walshe JL; Groen J; Johnsson P; Vidarsdóttir L; Grander D; Ataide SF; Morris KV
  • Proc Natl Acad Sci U S A 2017[Sep]; 114 (37): 9942-7 PMID28847966show ga
  • In recent years, noncoding RNA transcripts have been found to interact with genes and modulate their ability to be transcribed and made into protein. Here we uncover many of the mechanistic underpinnings involved in how noncoding RNAs control gene transcription. Notably, we find that noncoding RNA control of gene transcription is based on a combination of structural and sequence components of the noncoding RNA and targeted gene. Collectively, the observations presented here suggest that a much more complex and vibrant RNA regulatory world is operative in gene expression and evolution of the genome.
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