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10.1073/pnas.1616600114 http://scihub22266oqcxt.onion/10.1073/pnas.1616600114 C5603988!5603988!28847951     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (37): E7727-36 Nephropedia Template TP {{tp|p=28847951|t=2017. Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity |pdf=|usr=}}{{28847951}} gab.com Text Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28847951 #FOAvip We report a forward genetic screen to identify genes involved in cell adhesion and motility. Cells with mutations in these genes have increased adhesion, flattened morphology, and decreased motility. The mutants display increased cytoskeletal and signal transduction network activity suggesting that these genes are negative regulators. The GFP-tagged localization of these proteins shows the remarkable diversity in the regulation of these cell behaviors. Several of the identified proteins have strong homologs throughout metazoans and have relevance to human disease. Because many of the resulting mutant phenotypes are similar to those of cells lacking PTEN or expressing active Ras GTPases, these gene families are promising cancer targets in humans. Better understanding of these pathways holds the possibility for therapeutic intervention. Twit Text FOAVip Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28847951 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28847951 #FOAvip English Wikipedia <ref>{{Cite pmid|28847951}}</ref> Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity #MMPMID28847951 Lampert TJ; Kamprad N; Edwards M; Borleis J; Watson AJ; Tarantola M; Devreotes PN Proc Natl Acad Sci U S A 2017[Sep]; 114 (37): E7727-36 PMID28847951show ga We report a forward genetic screen to identify genes involved in cell adhesion and motility. Cells with mutations in these genes have increased adhesion, flattened morphology, and decreased motility. The mutants display increased cytoskeletal and signal transduction network activity suggesting that these genes are negative regulators. The GFP-tagged localization of these proteins shows the remarkable diversity in the regulation of these cell behaviors. Several of the identified proteins have strong homologs throughout metazoans and have relevance to human disease. Because many of the resulting mutant phenotypes are similar to those of cells lacking PTEN or expressing active Ras GTPases, these gene families are promising cancer targets in humans. Better understanding of these pathways holds the possibility for therapeutic intervention. äShear force-based genetic screen reveals negative regulators of cell a(epmc).pdf DeepDyve Pubget Overpricing