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10.1073/pnas.1616600114 http://scihub22266oqcxt.onion/10.1073/pnas.1616600114 C5603988!5603988 !28847951     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28847951 &cmd=llinks): Failed to open stream: HTTP request failed! 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Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity |pdf=|usr=}}{{28847951 }} gab.com Text Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28847951 #FOAvip The model organism Dictyostelium discoideum has greatly facilitated our understanding of the signal transduction and cytoskeletal pathways that govern cell motility. Cell-substrate adhesion is downstream of many migratory and chemotaxis signaling events. Dictyostelium cells lacking the tumor suppressor PTEN show strongly impaired migratory activity and adhere strongly to their substrates. We reasoned that other regulators of migration could be obtained through a screen for overly adhesive mutants. A screen of restriction enzyme-mediated integration mutagenized cells yielded numerous mutants with the desired phenotypes, and the insertion sites in 18 of the strains were mapped. These regulators of adhesion and motility mutants have increased adhesion and decreased motility. Characterization of seven strains demonstrated decreased directed migration, flatness, increased filamentous actin-based protrusions, and increased signal transduction network activity. Many of the genes share homology to human genes and demonstrate the diverse array of cellular networks that function in adhesion and migration. Twit Text FOAVip Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28847951 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28847951 #FOAvip English Wikipedia <ref>{{Cite pmid|28847951 }}</ref> Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity #MMPMID28847951 Lampert TJ ; Kamprad N ; Edwards M ; Borleis J ; Watson AJ ; Tarantola M ; Devreotes PN Proc Natl Acad Sci U S A 2017[Sep]; 114 (37 ): E7727-E7736 PMID28847951 show ga The model organism Dictyostelium discoideum has greatly facilitated our understanding of the signal transduction and cytoskeletal pathways that govern cell motility. Cell-substrate adhesion is downstream of many migratory and chemotaxis signaling events. Dictyostelium cells lacking the tumor suppressor PTEN show strongly impaired migratory activity and adhere strongly to their substrates. We reasoned that other regulators of migration could be obtained through a screen for overly adhesive mutants. A screen of restriction enzyme-mediated integration mutagenized cells yielded numerous mutants with the desired phenotypes, and the insertion sites in 18 of the strains were mapped. These regulators of adhesion and motility mutants have increased adhesion and decreased motility. Characterization of seven strains demonstrated decreased directed migration, flatness, increased filamentous actin-based protrusions, and increased signal transduction network activity. Many of the genes share homology to human genes and demonstrate the diverse array of cellular networks that function in adhesion and migration. |Actin Cytoskeleton/metabolism [MESH] |Actins/metabolism [MESH] |Cell Adhesion/*genetics [MESH] |Cell Movement/genetics [MESH] |Chemotaxis/genetics/physiology [MESH] |Cyclic AMP/metabolism [MESH] |Cytoskeleton/metabolism [MESH] |Dictyostelium/*genetics/metabolism [MESH] |Genetic Testing/*methods [MESH] |Protozoan Proteins/metabolism [MESH] |Shear Strength/physiology [MESH]Shear force-based genetic screen reveals negative regulators of cell a(epmc).pdf DeepDyve Pubget Overpricing