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10.1038/s41467-017-00654-w http://scihub22266oqcxt.onion/10.1038/s41467-017-00654-w C5603578!5603578 !28924218     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28924218 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 578 Nephropedia Template TP {{tp|p=28924218 |t=2017. Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1 |pdf=|usr=}}{{28924218 }} gab.com Text Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28924218 #FOAvip Coronary artery anomalies may cause life-threatening cardiac complications; however, developmental mechanisms underpinning coronary artery formation remain ill-defined. Here we identify an angiogenic cell population for coronary artery formation in mice. Regulated by a DLL4/NOTCH1/VEGFA/VEGFR2 signaling axis, these angiogenic cells generate mature coronary arteries. The NOTCH modulator POFUT1 critically regulates this signaling axis. POFUT1 inactivation disrupts signaling events and results in excessive angiogenic cell proliferation and plexus formation, leading to anomalous coronary arteries, myocardial infarction and heart failure. Simultaneous VEGFR2 inactivation fully rescues these defects. These findings show that dysregulated angiogenic precursors link coronary anomalies to ischemic heart disease.Though coronary arteries are crucial for heart function, the mechanisms guiding their formation are largely unknown. Here, Wang et al. identify a unique, endocardially-derived angiogenic precursor cell population for coronary artery formation in mice and show that a DLL4/NOTCH1/VEGFA/VEGFR2 signaling axis is key for coronary artery development. Twit Text FOAVip Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28924218 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28924218 #FOAvip English Wikipedia <ref>{{Cite pmid|28924218 }}</ref> Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1 #MMPMID28924218 Wang Y ; Wu B ; Lu P ; Zhang D ; Wu B ; Varshney S ; Del Monte-Nieto G ; Zhuang Z ; Charafeddine R ; Kramer AH ; Sibinga NE ; Frangogiannis NG ; Kitsis RN ; Adams RH ; Alitalo K ; Sharp DJ ; Harvey RP ; Stanley P ; Zhou B Nat Commun 2017[Sep]; 8 (1 ): 578 PMID28924218 show ga Coronary artery anomalies may cause life-threatening cardiac complications; however, developmental mechanisms underpinning coronary artery formation remain ill-defined. Here we identify an angiogenic cell population for coronary artery formation in mice. Regulated by a DLL4/NOTCH1/VEGFA/VEGFR2 signaling axis, these angiogenic cells generate mature coronary arteries. The NOTCH modulator POFUT1 critically regulates this signaling axis. POFUT1 inactivation disrupts signaling events and results in excessive angiogenic cell proliferation and plexus formation, leading to anomalous coronary arteries, myocardial infarction and heart failure. Simultaneous VEGFR2 inactivation fully rescues these defects. These findings show that dysregulated angiogenic precursors link coronary anomalies to ischemic heart disease.Though coronary arteries are crucial for heart function, the mechanisms guiding their formation are largely unknown. Here, Wang et al. identify a unique, endocardially-derived angiogenic precursor cell population for coronary artery formation in mice and show that a DLL4/NOTCH1/VEGFA/VEGFR2 signaling axis is key for coronary artery development. |Animals [MESH] |Cell Proliferation/genetics [MESH] |Coronary Artery Disease/*genetics/physiopathology [MESH] |Echocardiography [MESH] |Fucosyltransferases/deficiency/*genetics [MESH] |Intracellular Signaling Peptides and Proteins/deficiency/genetics [MESH] |Membrane Proteins/deficiency/genetics [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Neovascularization, Physiologic/*genetics [MESH] |Signal Transduction/*genetics [MESH] |Vascular Endothelial Growth Factor Receptor-2/deficiency/genetics [MESH]Uncontrolled angiogenic precursor expansion causes coronary artery ano(epmc).pdf DeepDyve Pubget Overpricing