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10.1016/j.tet.2016.11.016

http://scihub22266oqcxt.onion/10.1016/j.tet.2016.11.016
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C5603183!5603183!28943665
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suck abstract from ncbi


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pmid28943665      Tetrahedron 2017 ; 73 (29): 4206-13
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  • The intramolecular click reaction using ?carbocontiguous? precursors #MMPMID28943665
  • Patil PC; Luzzio FA
  • Tetrahedron 2017[Jul]; 73 (29): 4206-13 PMID28943665show ga
  • The synthesis and utilization of all carbon-chain ?carbocontiguous? azidoalkynyl precursors for an intramolecular click reaction is described. The substrates contain both azidoalkyl and ethynylmethyl groups which are conjoined by a 2-(phenylsulfonylmethyl)-4,5-diphenyloxazole lynchpin and are suitably disposed for ring closure. On promotion by copper salts, a number of cyclic click products having the 1,4-disubstituted endo-fused triazole component and the 4,5-diphenyloxazole component are obtained. In one case, removal of the phenylsulfonylmethyl group from the substrate prior to cyclization gave the 1,5-disubstituted exo-fused triazole. The utilization of CuSO4/sodium ascorbate system appears to be the optimal conditions for closure/cyclization and afforded the cyclized products in yields of 84-95%.
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