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10.1016/j.omtm.2017.08.003 http://scihub22266oqcxt.onion/10.1016/j.omtm.2017.08.003 C5602877!5602877!28948187     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28948187&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Ther+Methods+Clin+Dev 2017 ; 7 (ä): 20-31 Nephropedia Template TP {{tp|p=28948187|t=2017. Profiling the Targets of Protective CD8+ T Cell Responses to Infection |pdf=|usr=}}{{28948187}} gab.com Text Profiling the Targets of Protective CD8+ T Cell Responses to Infection JO: Mol Ther Methods Clin Dev http://www.kidney.de/pget.php?&tw=1&pmid=28948187 #FOAvip T cells are critical effectors of host immunity that target intracellular pathogens, such as the causative agents of HIV, tuberculosis, and malaria. The development of vaccines that induce effective cell-mediated immunity against such pathogens has proved challenging; for tuberculosis and malaria, many of the antigens targeted by protective T cells are not known. Here, we report a novel approach for screening large numbers of antigens as potential targets of T cells. Malaria provides an excellent model to test this antigen discovery platform because T cells are critical mediators of protection following immunization with live sporozoite vaccines and the specific antigen targets are unknown. We generated an adenovirus array by cloning 312 highly expressed pre-erythrocytic Plasmodium yoelii antigens into adenovirus vectors using high-throughput methodologies. The array was screened to identify antigen-specific CD8+ T cells induced by a live sporozoite vaccine regimen known to provide high levels of sterile protection mediated by CD8+ T cells. We identified 69 antigens that were targeted by CD8+ T cells induced by this vaccine regimen. The antigen that recalled the highest frequency of CD8+ T cells, PY02605, induced protective responses in mice, demonstrating proof of principle for this approach in identifying antigens for vaccine development. Twit Text FOAVip Profiling the Targets of Protective CD8+ T Cell Responses to Infection ????Mol Ther Methods Clin Dev http://www.kidney.de/pget.php?&tw=1&pmid=28948187 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28948187 #FOAvip English Wikipedia <ref>{{Cite pmid|28948187}}</ref> Profiling the Targets of Protective CD8+ T Cell Responses to Infection #MMPMID28948187 Bruder JT; Chen P; Ekberg G; Smith EC; Lazarski CA; Myers BA; Bolton J; Sedegah M; Villasante E; Richie TL; King CR; Aguiar JC; Doolan DL; Brough DE Mol Ther Methods Clin Dev 2017[Dec]; 7 (ä): 20-31 PMID28948187show ga T cells are critical effectors of host immunity that target intracellular pathogens, such as the causative agents of HIV, tuberculosis, and malaria. The development of vaccines that induce effective cell-mediated immunity against such pathogens has proved challenging; for tuberculosis and malaria, many of the antigens targeted by protective T cells are not known. Here, we report a novel approach for screening large numbers of antigens as potential targets of T cells. Malaria provides an excellent model to test this antigen discovery platform because T cells are critical mediators of protection following immunization with live sporozoite vaccines and the specific antigen targets are unknown. We generated an adenovirus array by cloning 312 highly expressed pre-erythrocytic Plasmodium yoelii antigens into adenovirus vectors using high-throughput methodologies. The array was screened to identify antigen-specific CD8+ T cells induced by a live sporozoite vaccine regimen known to provide high levels of sterile protection mediated by CD8+ T cells. We identified 69 antigens that were targeted by CD8+ T cells induced by this vaccine regimen. The antigen that recalled the highest frequency of CD8+ T cells, PY02605, induced protective responses in mice, demonstrating proof of principle for this approach in identifying antigens for vaccine development. äProfiling the Targets of Protective CD8+ T Cell Responses to Infection(epmc).pdf DeepDyve Pubget Overpricing