Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28948167
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Biomed+Res+Int
2017 ; 2017
(ä): 5123148
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The Glymphatic Hypothesis of Glaucoma: A Unifying Concept Incorporating Vascular,
Biomechanical, and Biochemical Aspects of the Disease
#MMPMID28948167
Wostyn P
; De Groot V
; Van Dam D
; Audenaert K
; Killer HE
; De Deyn PP
Biomed Res Int
2017[]; 2017
(ä): 5123148
PMID28948167
show ga
The pathophysiology of primary open-angle glaucoma is still largely unknown,
although a joint contribution of vascular, biomechanical, and biochemical factors
is widely acknowledged. Since glaucoma is a leading cause of irreversible
blindness worldwide, exploring its underlying pathophysiological mechanisms is
extremely important and challenging. Evidence from recent studies appears
supportive of the hypothesis that a "glymphatic system" exists in the eye and
optic nerve, analogous to the described "glymphatic system" in the brain. As
discussed in the present paper, elucidation of a glymphatic clearance pathway in
the eye could provide a new unifying hypothesis of glaucoma that can incorporate
many aspects of the vascular, biomechanical, and biochemical theories of the
disease. It should be stressed, however, that the few research data currently
available cannot be considered as proof of the existence of an "ocular glymphatic
system" and that much more studies are needed to validate this possibility. Even
though nothing conclusive can yet be said, the recent reports suggesting a
paravascular transport system in the eye and optic nerve are encouraging and, if
confirmed, may offer new perspectives for the development of novel diagnostic and
therapeutic strategies for this devastating disorder.