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10.1016/j.neo.2017.08.004 http://scihub22266oqcxt.onion/10.1016/j.neo.2017.08.004 C5602478!5602478 !28923537     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28923537 &cmd=llinks): Failed to open stream: HTTP request failed! 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Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients |pdf=|usr=}}{{28923537 }} gab.com Text Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients JO: Neoplasia http://www.kidney.de/pget.php?&tw=1&pmid=28923537 #FOAvip This is the first prospective study of the effects of human gut microbiota and metabolites on immune checkpoint inhibitor (ICT) response in metastatic melanoma patients. Whereas many melanoma patients exhibit profound response to ICT, there are fewer options for patients failing ICT-particularly with BRAF-wild-type disease. In preclinical studies, specific gut microbiota promotes regression of melanoma in mice. We therefore conducted a study of the effects of pretreatment gut microbiota and metabolites on ICT Response Evaluation Criteria in Solid Tumors response in 39 metastatic melanoma patients treated with ipilimumab, nivolumab, ipilimumab plus nivolumab (IN), or pembrolizumab (P). IN yielded 67% responses and 8% stable disease; P achieved 23% responses and 23% stable disease. ICT responders for all types of therapies were enriched for Bacteroides caccae. Among IN responders, the gut microbiome was enriched for Faecalibacterium prausnitzii, Bacteroides thetaiotamicron, and Holdemania filiformis. Among P responders, the microbiome was enriched for Dorea formicogenerans. Unbiased shotgun metabolomics revealed high levels of anacardic acid in ICT responders. Based on these pilot studies, both additional confirmatory clinical studies and preclinical testing of these bacterial species and metabolites are warranted to confirm their ICT enhancing activity. Twit Text FOAVip Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients ????Neoplasia http://www.kidney.de/pget.php?&tw=1&pmid=28923537 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28923537 #FOAvip English Wikipedia <ref>{{Cite pmid|28923537 }}</ref> Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients #MMPMID28923537 Frankel AE ; Coughlin LA ; Kim J ; Froehlich TW ; Xie Y ; Frenkel EP ; Koh AY Neoplasia 2017[Oct]; 19 (10 ): 848-855 PMID28923537 show ga This is the first prospective study of the effects of human gut microbiota and metabolites on immune checkpoint inhibitor (ICT) response in metastatic melanoma patients. Whereas many melanoma patients exhibit profound response to ICT, there are fewer options for patients failing ICT-particularly with BRAF-wild-type disease. In preclinical studies, specific gut microbiota promotes regression of melanoma in mice. We therefore conducted a study of the effects of pretreatment gut microbiota and metabolites on ICT Response Evaluation Criteria in Solid Tumors response in 39 metastatic melanoma patients treated with ipilimumab, nivolumab, ipilimumab plus nivolumab (IN), or pembrolizumab (P). IN yielded 67% responses and 8% stable disease; P achieved 23% responses and 23% stable disease. ICT responders for all types of therapies were enriched for Bacteroides caccae. Among IN responders, the gut microbiome was enriched for Faecalibacterium prausnitzii, Bacteroides thetaiotamicron, and Holdemania filiformis. Among P responders, the microbiome was enriched for Dorea formicogenerans. Unbiased shotgun metabolomics revealed high levels of anacardic acid in ICT responders. Based on these pilot studies, both additional confirmatory clinical studies and preclinical testing of these bacterial species and metabolites are warranted to confirm their ICT enhancing activity. |*Gastrointestinal Microbiome [MESH] |*Metabolomics/methods [MESH] |*Metagenome [MESH] |*Metagenomics/methods [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Antineoplastic Agents, Immunological/pharmacology/therapeutic use [MESH] |Biomarkers, Tumor [MESH] |Chromatography, High Pressure Liquid [MESH] |Cluster Analysis [MESH] |Female [MESH] |High-Throughput Nucleotide Sequencing [MESH] |Humans [MESH] |Male [MESH] |Melanoma/drug therapy/*etiology/*metabolism/pathology [MESH] |Middle Aged [MESH] |Molecular Targeted Therapy [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Staging [MESH] |Prognosis [MESH] |Tandem Mass Spectrometry [MESH]Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Iden(epmc).pdf DeepDyve Pubget Overpricing