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10.1080/15384101.2017.1325039 http://scihub22266oqcxt.onion/10.1080/15384101.2017.1325039 C5602426!5602426!28816574     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28816574&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Cycle 2017 ; 16 (18): 1683-94 Nephropedia Template TP {{tp|p=28816574|t=2017. SGT1-HSP90 complex is required for CENP-A deposition at centromeres |pdf=|usr=}}{{28816574}} gab.com Text SGT1-HSP90 complex is required for CENP-A deposition at centromeres JO: Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=28816574 #FOAvip The centromere plays an essential role in accurate chromosome segregation, and defects in its function lead to aneuploidy and thus cancer. The centromere-specific histone H3 variant CENP-A is proposed to be the epigenetic mark of the centromere, as active centromeres require CENP-A?containing nucleosomes to direct the recruitment of multiple kinetochore proteins. CENP-A K124 ubiquitylation, mediated by CUL4A-RBX1-COPS8 E3 ligase activity, is required for CENP-A deposition at the centromere. However, the mechanism that controls the E3 ligase activity of the CUL4A-RBX1-COPS8 complex remains obscure. We have discovered that the SGT1-HSP90 complex is required for recognition of CENP-A by COPS8. Thus, the SGT1-HSP90 complex contributes to the E3 ligase activity of the CUL4A complex that is necessary for CENP-A ubiquitylation and CENP-A deposition at the centromere. Twit Text FOAVip SGT1-HSP90 complex is required for CENP-A deposition at centromeres ????Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=28816574 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28816574 #FOAvip English Wikipedia <ref>{{Cite pmid|28816574}}</ref> SGT1-HSP90 complex is required for CENP-A deposition at centromeres #MMPMID28816574 Niikura Y; Kitagawa R; Ogi H; Kitagawa K Cell Cycle 2017[]; 16 (18): 1683-94 PMID28816574show ga The centromere plays an essential role in accurate chromosome segregation, and defects in its function lead to aneuploidy and thus cancer. The centromere-specific histone H3 variant CENP-A is proposed to be the epigenetic mark of the centromere, as active centromeres require CENP-A?containing nucleosomes to direct the recruitment of multiple kinetochore proteins. CENP-A K124 ubiquitylation, mediated by CUL4A-RBX1-COPS8 E3 ligase activity, is required for CENP-A deposition at the centromere. However, the mechanism that controls the E3 ligase activity of the CUL4A-RBX1-COPS8 complex remains obscure. We have discovered that the SGT1-HSP90 complex is required for recognition of CENP-A by COPS8. Thus, the SGT1-HSP90 complex contributes to the E3 ligase activity of the CUL4A complex that is necessary for CENP-A ubiquitylation and CENP-A deposition at the centromere. äSGT1-HSP90 complex is required for CENP-A deposition at centromeres (epmc).pdf DeepDyve Pubget Overpricing